* denotes 2023 Innovation Award Winner
Electrospin/spray for production of high mitigant-loaded fabricsThis technology is a new fabric production method that has unprecedented control over the particle loading in a loaded fabric system. We will use this approach to prepare fabrics that simultaneously protect from chemical threats and improve wearer comfort.
The Cog-Sobriety™ a Work Accident Reduction Tool: On-demand Cognitive Sobriety Test in 30 Seconds - Detect impairments regardless of underlying CAUSECog-Sobriety™ uses involuntary reaction times of the visual cortex to detect impairment and it can detect the level of impairment due to: Prescription drugs Illegal drugs Alcohol Sleep deprivation Residual effects of head trauma Others employees can be checked before the start of their shift or field deployment
A New Drug for Traumatic Brain InjurySRX251 is a mechanism-based breakthrough drug that reduces or eliminates the short- and long-term effects of non-penetrating mild and moderate Traumatic Brain Injuries. A selective vasopressin 1a receptor antagonist, SRX251 targets a pathway that underlies the brain damage, cognitive effects, and long-term risks from these injuries.
An Orally Delivered Transuranic Element Nuclear Chelator TherapeuticC2E2 is an orally bioavailable, self-administered, water mixable powder which, when swallowed, enters the bloodstream and binds to radioactive and nonradioactive metals such as plutonium, americium, lead, and gadolinium which are then excreted via the kidneys allowing for rapid corporal removal to prevent tissue deposition and long term damage.
KWYN‚Ñ¢ EFECTIVEEFECTIVE is an AI-guided, simulation for training mass casualty response skills. Targeting first responders, incident commanders, and logistics personnel, it provides phone, computer, and virtual reality training options. Embedded AI is used to simulate virtual teammates, automatically assess skill level, and generate novel, skill-appropriate scenarios for each learner.
MIDNIGHT: Monitoring and Inspecting Dirty Nukes Including Generating Heat Maps of TerrainMIDNIGHT conducts autonomous surveys to identify and map the location of radiological threats using small UAS. MIDNIGHT simultaneously localizes and maps gamma ray and neutron radiation providing real-time meter-resolution accuracy using state-of-the-art computer vision techniques to construct a volumetric 3D representation of the region of interest.
A Software Tool for Microbubble Enhanced HIFU for Non-invasive Tumor AblationsOur innovative software leads to a revolutionary breakthrough of non-invasive tumor ablations by enabling customized microbubble targeting ultrasonic therapies for deep-seated tumors in clinical setting, which works as tumor Treatment Planning Software for therapist, and a design tool for HIFU manufactures to improve efficacy and safety of HIFU devices.
A Wearable Diamond Sensor of Ionizing RadiationEuclid proposes a light, very compact, wearable, on-chip diamond sensor for all kinds of ionizing radiation including neutron fluxes. The idea is based on measuring the change in properties of RF resonator where diamond is exposed by ionizing radiation. Our sensor is sensitive, robust, can be fed from mobile phone.
Engineered protein for tissue protectionWe have developed a protein to treat radiation poisoning, traumatic brain injury, organophosphate poisoning and similar traumas. The protein is engineered so that a single injection works for at least several days, and it crosses the blood-brain barrier to provide extra protection of the nervous system against long-term damage.
Next-generation protein sequencing for pathogen agnostic and massively parallel infectious disease diagnosticsDNA sequencing and RNA therapeutics have revolutionized the medical and biodefense worlds but sequencing proteins that underpin cellular pathogenicity remains slow and expensive. Glyphic Bio's single-molecule protein sequencing platform identifies all proteins in a sample to enable rapid diagnosis of known diseases and the detection of novel, emerging threats
Point of Use CBRN FilterThe Point of Use (POU) CBRN Filter is a filtration system designed to integrate into existing building ductwork, providing CBRN protection to discrete locations, such as conferences rooms or control centers without upgrading the building‚Äôs current air handling system.
Self-Detoxifying GarmentThe Self-Detoxifying Garment is a garment with increased chemical protection, enhanced performance in the presence of battlefield contaminants (fuel), minimal degradation following washing while also delivering a reduced thermal burden to the warfighter. It incorporates composite materials and reactive barrier materials to increase both CBRN protection and comfort.
Tachyon GuardianIntroducing the Tachyon Guardian, an AI-driven gene expression-based POC diagnostic platform designed for the Defence industry. Specialising in biodosimetry, it revolutionises radiological incident response by enhancing triage efficiency and predicting acute radiation syndrome outcomes. The Tachyon Guardian ensures rapid, accurate assessments, safeguarding personnel and civilians in high-stakes radiological emergencies.
Sensor-integrated proteome on-chip (SPOC‚Ñ¢): a multiplexed pan-pathogen detection platformProteins are the functional elements of biology. However, traditional, costly protein production methods limit the ability to evaluate their role in disease. INanoBio developed the world‚Äôs first technology to produce >1000 proteins directly on biosensors. We are developing a pan-pathogen biosensor chip to aid in diagnostics, therapeutic evaluation, and prognostics.
Recognize- A first-in-class diagnostic platformWe are developing a first-in-class medical diagnostic that will enable the pre-symptomatic, accurate, and rapid detection of pathogens. Our technology is adaptable to disease-specific cartridges. It will be game-changing on the battlefield, with a rapid and accurate diagnosis, saving soldiers' lives, and will help through any future pandemics.
The Protein ProFiler‚Ñ¢: A Microfluidic Solution to the Biomarker ComplexityWith >1,000,000 proteins in humans exhibiting a unique signature of any of >400 different metabolically applied chemical modifications, current technology cannot address this combinatorial complexity. To identify CBW/DEW exposures to the warfighter‚Äîpre-symptomatically‚Äîaccurate biomarkers of toxicity must be discovered and diagnosed. The ProFiler is uniquely suited to accomplish this task.
Machine Learning for Multi-modal CBRN Threat Classification and LocalizationWe propose a chemical threat detection system that leverages drones, computer vision, multimodal machine learning, and chemical detection technologies to provide an operator with an improved tool to identify and respond to chemical threats more rapidly and with more autonomy.
Rapid, low-cost, scalable biothreat response platformBiodefense threats are too numerous and mutable for us to develop advance countermeasures against them all. Developing countermeasures upon emergence is also infeasible‚Äîto many people die in the interim. Lumen offers a third path: a rapid, inexpensive platform for making safe, effective biologic drugs, on demand.
Thermobrachytherapy Oncology Platform Medical DeviceThermobrachytherapy device incorporates temporary balloon implant and induction system to treat at-risk tissue post-resection. A potent therapeutic thermal enhancement by delivery of simultaneous heat and radiation. Treatment delivered immediately post resection before cancer cells migrate, significantly enhancing local response and survival while minimizing peripheral toxicity and improve clinical outcomes.
A platform technology for soft tissue repairMatregenix developed MatriNova, a new platform technology for soft-tissue repair applications. For clinicians with patients requiring soft-tissue repair, MatriNova is a programable nonbiologic, antimicrobial, hybrid-scale fiber matrix engineered to be similar to human extracellular matrix that activates granulation tissue while maintaining tensile strength with flexibility.
A Field Rugged and Mobile Aerosol Particulate Analytical Laboratory with Aerial Drone Sampling CapabilityThe technical system provides for the collection of air particulate samples for on or near site gravimetric analysis, chemical speciation and PRC testing in order to obtain high quality data, which is traceable to SI units, and to evaluate and monitor the threat of CBRN hazards in airborne particulates.
Antibody Platform for Detection and Treatment of Bioterrorism AttacksRapid test in the field using antibodies (akin to a COVID swab or pregnancy urine test) to detect a bioterrorism event, diagnose the specific toxin used, and then provide rapid injectable antibody treatment before the onset of symptoms.
A lean, affordable robotic technology that provides a unique functionality and option to current robotic furniture / assisted access productsOur lean, low-cost novel robotic technology provides the unique functionality of moving outward to clear any objects beneath it, then lowering a wall-mounted cabinet (mounted at 72 inches high) as much as 3 feet to bring the cabinet to within arm's reach of a person who uses a wheelchair.
Advancing CBRN Protection with MOFsCurrent CBRN protection equipment lacks the flexibility to adapt to the modern threat landscape. The sorbent materials powering CBRN protection have well-understood deficiencies and little room for improvement. When used appropriately, advanced metal-organic-framework (MOF) sorbents offer a path forward for vastly improved masks, filters, suits, wipes, coatings, and more.
A Negative Pressure Protective Barrier Enclosure: The STAT EnclosureThe STAT Enclosure is a single-patient-use, lightweight, foldable protective barrier enclosure designed to mitigate healthcare worker exposure to hazardous pathogens during aerosol-generating procedures such as endotracheal intubation. The device utilizes a battery-powered vacuum and is compatible with hospital beds and NATO litters. Pending FDA Approval.
Sensible PCR PlatformSensible‚Äôs Rapid PCR platform is designed to test patients for infectious diseases using PCR technology at the point-of-care. Sensible‚Äôs platform was developed based on pandemic-testing principles. Sensible‚Äôs platform can generate a fully-automated, real-time PCR result in 10 minutes for the same price as a rapid antigen test.
A safe, rapid, and effective way to cure gum diseaseSingletO2 Therapeutics has developed a patented device to safely, rapidly and effectively treat gum disease (periodontitis). The tip of the device's optical fiber, inserted into the periodontal pocket, painlessly kills the bacteria that cause periodontitis without using antibiotics. This game-changing technology is safer and more effective than current treatments.
Next generation diagnostic and therapeutic bone fracture healingSonogen Medical is working to commercialize a ground-breaking ultrasonic bone growth stimulation device that optimizes bone fracture healing while providing real-time feedback on both patient compliance and the fracture healing process.
Capillary-Embedded Rapid Adaptable Multiscale (CERAM) Bioprinting for Engineering Large Vascularized TissuesThe proposed technology represents a novel hybrid 3D bioprinting approach that can rapidly incorporate thousands of porous microtubes that function as capillary vessels to a centimeter-sized 3D printed scaffold within several minutes. The proposed invention is 10-fold faster and exhibits 10-fold higher resolution than existing technologies.
Enclosed Hollow Needle Blister-Packs for Drug DeliveryA blister pack that contains a prefilled amount of vaccine or other medicine that can be administered by pressing the blister pack against the patient where the enclosed hollow needle inside the blister pack will inject the medication into the patient.
Biomimicking Photocrosslinkable Nanocomposite Bone GraftsWe develop Biomimicking Photocrosslinkable Nanocomposite Bone Grafts, which mirror the structure of natural bone and are fabricated under simple conditions. The bone grafts can load and release bioactive molecules, activate cell signaling pathways to simultaneously promote osteogenesis and angiogenesis, while providing optimal mechanical support to the injured area, expediting the bone healing process.
Software to model immune biological responses across multiple biological scalesAs opposed to modeling a component of the human immune system in infinite detail, our software accounts for 29 immune cell types to model communication at the population, organ, cellular, and intracellular (metabolic) levels. This allows for a more precise response prediction to immune threats.
Rough Adhesive Hydrogels (RAd gels) Non-catechol based adhesive hydrogelsA biocompatible hydrogels that exhibits robust adhesion in wet conditions to substrates with wide range of chemistries and moduli.
Stretchable, Adhesive, and Self-Healing Hydrogels for Next-Generation AdhesivesA hydrogel that can naturally stretch and self-heal while adhering to the body, enabling new designs for medical adhesives.
Surface Ionization Noncontact Extended-Wear (SINEW) MaskThe Surface Ionization Noncontact Extended-Wear (SINEW) Mask revolutionizes personal respiratory protection by utilizing noncontact, wearable electrostatic filters. By harnessing miniaturized high-voltage electronics and advanced catalytic coatings, SINEW Mask eliminates airborne threats without compromising comfort, communication, or usability. Fundamentally, the mask protects against harmful particulate matter without touching the wearer‚Äôs face.
Vaccine Microarray Patch / VaxiPatchVerndari's VaxiPatch, is a thermostable, intradermal microarray vaccine delivery system designed to be a universal, easy-to-use, painless, dose-sparing delivery method with the potential to be self-administered, streamlining vaccine administration. The system is being developed for high-speed manufacturing, reducing cold chain requirements and medical waste.