* denotes 2023 Innovation Award Winner
A New Drug for Traumatic Brain InjurySRX251 is a mechanism-based breakthrough drug that reduces or eliminates the short- and long-term effects of non-penetrating mild and moderate Traumatic Brain Injuries. A selective vasopressin 1a receptor antagonist, SRX251 targets a pathway that underlies the brain damage, cognitive effects, and long-term risks from these injuries.
An Orally Delivered Transuranic Element Nuclear Chelator TherapeuticC2E2 is an orally bioavailable, self-administered, water mixable powder which, when swallowed, enters the bloodstream and binds to radioactive and nonradioactive metals such as plutonium, americium, lead, and gadolinium which are then excreted via the kidneys allowing for rapid corporal removal to prevent tissue deposition and long term damage.
Point of Use CBRN FilterThe Point of Use (POU) CBRN Filter is a filtration system designed to integrate into existing building ductwork, providing CBRN protection to discrete locations, such as conferences rooms or control centers without upgrading the building‚Äôs current air handling system.
Self-Detoxifying GarmentThe Self-Detoxifying Garment is a garment with increased chemical protection, enhanced performance in the presence of battlefield contaminants (fuel), minimal degradation following washing while also delivering a reduced thermal burden to the warfighter. It incorporates composite materials and reactive barrier materials to increase both CBRN protection and comfort.
Rapid, low-cost, scalable biothreat response platformBiodefense threats are too numerous and mutable for us to develop advance countermeasures against them all. Developing countermeasures upon emergence is also infeasible‚Äîto many people die in the interim. Lumen offers a third path: a rapid, inexpensive platform for making safe, effective biologic drugs, on demand.
A platform technology for soft tissue repairMatregenix developed MatriNova, a new platform technology for soft-tissue repair applications. For clinicians with patients requiring soft-tissue repair, MatriNova is a programable nonbiologic, antimicrobial, hybrid-scale fiber matrix engineered to be similar to human extracellular matrix that activates granulation tissue while maintaining tensile strength with flexibility.
A Field Rugged and Mobile Aerosol Particulate Analytical Laboratory with Aerial Drone Sampling CapabilityThe technical system provides for the collection of air particulate samples for on or near site gravimetric analysis, chemical speciation and PRC testing in order to obtain high quality data, which is traceable to SI units, and to evaluate and monitor the threat of CBRN hazards in airborne particulates.
Advancing CBRN Protection with MOFsCurrent CBRN protection equipment lacks the flexibility to adapt to the modern threat landscape. The sorbent materials powering CBRN protection have well-understood deficiencies and little room for improvement. When used appropriately, advanced metal-organic-framework (MOF) sorbents offer a path forward for vastly improved masks, filters, suits, wipes, coatings, and more.
A Negative Pressure Protective Barrier Enclosure: The STAT EnclosureThe STAT Enclosure is a single-patient-use, lightweight, foldable protective barrier enclosure designed to mitigate healthcare worker exposure to hazardous pathogens during aerosol-generating procedures such as endotracheal intubation. The device utilizes a battery-powered vacuum and is compatible with hospital beds and NATO litters. Pending FDA Approval.
Sensible PCR PlatformSensible‚Äôs Rapid PCR platform is designed to test patients for infectious diseases using PCR technology at the point-of-care. Sensible‚Äôs platform was developed based on pandemic-testing principles. Sensible‚Äôs platform can generate a fully-automated, real-time PCR result in 10 minutes for the same price as a rapid antigen test.
Software to model immune biological responses across multiple biological scalesAs opposed to modeling a component of the human immune system in infinite detail, our software accounts for 29 immune cell types to model communication at the population, organ, cellular, and intracellular (metabolic) levels. This allows for a more precise response prediction to immune threats.