Today's biomagnetic sensors are large, complex, and require heavy magnetic shielding to mitigate interference from ambient magnetic fields. We have developed a very high resolution magnetic sensor with low size, weight, power, and cost that has enhanced immunity to magnetic interference.
A Fetal Brain Oxygen Monitor
Brimrose Technology together with Johns Hopkins Hospital is developing a sensing system to measure the oxygen levels of the fetus while the mother is in labor. The quick identification of low oxygen levels and rapid correction will dramatically reduce infant mortality and brain disease such as cerebral palsy.
IPASS - non-invasive assessment of intracranial pressure
The IPASS device can assess intracranial pressure (ICP), which is the pressure in the fluid around the brain, without requiring a surgical procedure as in the current gold standard methods. ICP is important int he management of traumatic brain injury (TBI) to prevent secondary brain damage.
Joint Integrated Lifeline System (JILS)
JILS is a sensor-agnostic software system that integrates disparate data sources from various sensors and allows information display on a user interface to facilitate decision-making. JILS can translate data formats, normalize data, compress data, store data, encrypt the transmissions, and produce actionable output in a variety of network protocols.
Development of the haloanilide, ELP-004 to prevent arthritis-induced bone erosion by inhibiting osteoclast differentiation
ELP-004 is a drug to treat rheumatoid arthritis by directly targeting the cells that cause the bone erosion instead immune components elevated in arthritis. ELP-004 is not immunosuppressive. ELP-004 is a small molecule that is easy and inexpensive to produce and is effective when administered orally.
Novel Hydrogels to Heal Wounds Faster with Less Inflammation
GelSana’s novel hydrogels accelerate wound healing, particularly in inflammatory wounds. Based on their chemistry, the hydrogels provide a moist, protected, anti-inflammatory environment. They are easy to apply and remain stable in the wound. These hydrogels can deliver therapeutics in a sustained manner.
flowDx is a laser-based paper-patterning technology that that radically changes the performance and versatility of current lateral flow tests (LFTs)
Our innovative technology provides a route to delivering a step-change in the performance of LFTs by controlling the fluid-flow within. Laser patterning of the paper materials that build the LFTs allows the ‘clever’ flow-control and helps create next-generation LFTs, which allow for both multiplexing and semi-quantification and have enhanced sensitivity.
Floral Park, NY
Novel 4D Printing Technique for Treatment of Neurological and Orthopedic Disorders
4D Printing is a step up of 3D printing, allowing transplantation of stem cells in novel biotherapeutics such as Parkinson's Disease, and control over the shape of material even after implantation. We also aim to combat the opioid epidemic with our novel analgesic formulation implant
Prolonged Field Care Realistic Immersive Scenario Engine (PFC RISE)
PFC RISE is a rapidly scalable training and performance analytics ecosystem. Its focus is to help standardize training, provide access to geographically dispersed teams, maximize instructor effectiveness, and assess training performance. Tech Stack includes: Dynamic Scenario Authoring; Scenario Management; Physiology Engine; Human Performance Analytics
Post-traumatic Stress Disorder Diagnostic and Precision Treatment
Neurovation Labs, Inc. is developing the first-ever objective diagnostic and companion precision medication for Post-traumatic Stress Disorder (PTSD) based on a groundbreaking brain biomarker discovery. PTSD is frequently diagnosed in both military as well as civilians after exposure to trauma. Neurovation Labs is transforming mental healthcare from art to science.
Wearable thermoelectrics to heat, cool, and compress for mobile pain relief.
A wearable solution that accelerates return-to-readiness through a combination of heating, cooling, and compression. It provides safe and accurate temperatures (via thermoelectric coolers/Peltier module) and utilizes a novel compression mechanism to deliver safe yet custom treatment based on the needs/pains of the wearer.
A quick and safe protocol for virus concentration and nucleic acid extraction
The current innovation uses a simpler and faster method to concentrate viruses from large volumes of fluids such as city wastewater. It allows quick extraction of viral genomic material, which can be further analyzed to detect mutations and thereby identify possible rare variants of concern.
Strathclyde Minor Grove Binders (S-MGBs)
Current and future threats to global biosecurity are predominantly due to infectious pathogens. Our platform technology of molecules bind to DNA at multiple sites to kill pathogens of many different infectious disease types including bacteria, fungi, viruses and parasites, with a unique mechanism of action to delay resistance development.
Manufacturability of Stretchable Medical Wearable Electronics
High-performance alternatives to rigid electrodes are needed for biomedical use and physiological monitoring. Stretchable electrodes require highly flexible, low-profile, electrically conductive adhesives suited for direct silicon die (unprotected chip) attach. SRS is using its commercially available technology to produce dry electrodes manufacturable in high-volume in the USA.
Fractionation and Profiling of Heterogeneous Circulating Tumor Cells Using a Hyperuniform-Structured Microchip
The technology is a device used to isolate, identify and categorize in situ the circulating tumor cells (CTCs) that are present in later stages of most forms of cancer utilizing a hyperuniform microchip structure.
Portable In-Vivo Oxidative Stress (IVOS) Biosensor
Oxidative stress occurs when there is imbalance between production and accumulation of toxic free radicals which are normally produced during human metabolism. For the first time, this device enables continuous human metabolism and oxidative stress measurement, which can significantly enhance human performance during CBRN environments and for improved clinical outcomes.
Regulation of assembly status and activity of the proteasome as a non-toxic way to mitigate military relevant muscle atrophy
Loss of skeletal muscle mass and strength is a problem in military-relevant settings including operational stress or post-injury immobilization. In affected muscle cells disassembly of proteins progresses faster than their replenishment. We designed non-toxic small molecules that mitigate the protein loss and restore muscle health in animal model.
South Bend, IN
A Mechanical Device for Breast Cancer Diagnosis
MechDiag device detects breast cancers by analyzing a group of cells from a patient's tissue/blood sample. This is done by the application of stress to determine the cells' resistance (stiffness) to stress. This stiffness property is different in normal cells and can be used to diagnose patients with breast cancer.
Portable platform for mobile ELISA tests
We proposed and prototyped a very accurate, cost effective, small portable ELISA-based system that will be easy to use in every urgent care facility or point-of-care. Previously we demonstrated the first mobile ELISA measuring progesterone level with gold standard accuracy, that was able to support both incubation and plate reading.
NeuroVana - A Non-invasive and Portable Diagnostic-support Device for Brain Injury assessment
It is a non-invasive and portable screening technology to help physicians assess the likelihood of a head injury in minutes and track the recovery. The technology consists of a small and portable ultrasound device that connects with the proprietary software on cloud and gives the results directly on your device.
MIMIX™ Sustained Release Patch
MIMIX Patch stabilizes a wide range of molecules into a thin film strip which can be shipped and stored without refrigeration, eliminating the need for the cold-chain. When applied onto the skin, pharmaceutical-loaded biomaterials dissolve gradually in the body, enabling highly effective medicinal delivery and a more sustained immune response.
A Stimuli Responsive Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells and Glioma Cancer Stem Cells
The technology comprises an injectable hydrogel capable of sustained release of chemokines and sub-lethal electric fields that synergistically direct the selective migration of glioblastoma multiforme and glioma cancer stem cells into the hydrogel through chemotaxis and electrotaxis, respectively. Focused ultrasound can then ablate the entrapped cancer cells.
Personalized Medicine Using Additive Manufacturing
A method for additively manufacturing personalized dosage tablets with different polymer architectures. The method opens the door for achieving 3D printed tablets with improved structural stability and pharmacokinetics for personalized dosage medicine.
Compact image-guided system for focal delivery of drugs and electric fields to the brain
System will revolutionize the treatment of neurological and psychiatric disorders by non-invasively delivering and monitoring drugs and therapeutic electric fields using a built-in MRI
Los Angeles, CA
Rapid identification of Coronaviruses including SARS-CoV-2 and detection of its mutations.
Rapid diagnostic assay for the in-field identification of Coronaviruses including SARS-CoV-2 and the detection of mutations in its spike protein from human nasal, buccal or saliva samples. It can be used and easily read by individuals without medical expertise to provide integrated sample-to-answer in less than 30 minutes.