Proactive Health Management for all
Our Enterprise tool provides customizable, large group heath intelligence using a proprietary engine and wearable that collects HR|SpO2|Temp|Activity. Cohort data is analyzed for actionable insights and detecting “events” (e.g. fall, activity post training). A Command Center Application externalizes insights and enables Proactive Health Management and used in EMR systems
ACTJect - Autoinjector
A rugged and reliable medication delivery system for EMS first-responders, ER teams and Soldiers. Innovative design allows for quick conversion to intramuscular; intranasal; intravenous or intraosseous use. Employing a shielded needle to prevent needle-sticks and featuring environment proof casing with tactile input for harsh and non-permissive conditions.
VACNO: A Therapeutic Adjunctive Treatment For COVID-19
VACNO is being developed as a drug that would prevent or reverse the severe symptoms that lead to mortality in COVID-19 and other coronavirus infections. It has the potential to alleviate both respiratory distress symptoms and multiple organ failure, thereby decreasing mortality.
Novel Therapy to Accelerate Nerve Regeneration and Recovery in Acute Trauma
An existing therapeutic drug, Herceptin, currently extensively used for Breast Cancer has been shown to be effective in helping regeneration of nerves damaged by a traumatic event. This new application for the drug will be significant in improving recovery in patients with injuries from accidents, gun shots and blasts.
The BioPOD™: The Next Generation of Wearable Biosensing
Existing wearable biometric sensors seldom provide the needed durability, signal quality, and size, weight, and power for operational use. Aptima, UT, and NextFlex are developing a wearable biometric sensor known as the BioPOD™. The BioPOD™ provides a comfortable, lightweight mechanism for acquisition of a diverse set of physiological markers.
AHEAD (Areté Human Evaluation and Determination) System
AHEAD (Areté Human Emergency Analysis and Determination system) employs visual sensors and deep neural networks to find and assess combat casualties through accurate human detection, pose mapping, and precision surface volume modelling. The system also remotely measures pulse and detects wounds, helping administer timely and effective casualty care.
A data analytics platform for pain management and alternative treatment
Utilizing AI and machine learning, this technology will improve the delivery of alternative treatment and natural products for pain management. The technology will record patients' pain episodes, sleep patterns, exercises, treatment adherence, and emotional change. Population-level data will return the optimal alternative treatment personalized for patients with different demographic characteristics.
San Jose, CA
Novel PPE mask, in situ disinfection with UV-C LEDs, free breathing, reusable
A reusable active disinfection mask for occupational use to protect the wearer from the transfer of airborne microorganisms or body fluids. Mask includes advanced semiconductor UV-C emitters (272 nm) which had been verified to kill >99.999% (SAL 10-5) airborne bacterial and viral pathogens at typical breathing rates
3D and 4D GNC (Guidance, Navigation, & Control) for Augmented Reality in Surgery
3D-GNC and 4D-GNC provide next-generation image guidance for minimally invasive interventions and surgery. The platform combines compact, low-power electromagnetic tracking and anatomical mapping algorithms with 3D and 4D rendering and augmented reality, allowing computerized guidance without heavy X-ray use. The technology addresses needs ranging from combat casualty care to training.
A Wearable Device to Objectively Measure Pain
Pain is a major cause of suffering and disability at different levels in individuals and is one of the most frequent reasons for visiting a physician. At CereVu we have developed a wearable forehead device and demonstrated its efficacy as a means of objectively monitoring pain.
A Time-dependent Machine-Learning-based Prediction Model for Progression of Knee Osteoarthritis
This project aims to develop a novel Knee Osteoarthritis (KOA) progression prediction system with artificial intelligence and big data analytic approach to facilitate the short, mid, and long-term KOA treatment planning.
RF wearable, touchless vital-sign sensors by near-field coherent sensing
By placing the RF sensor on the chest (on garment or lanyard), detailed cardiopulmonary functions of heart rates, breath rates, respiratory volume, central blood pressures, breath sounds and their variabilities can be retrieved for wellness evaluation or diagnostics. The sensor can be put on wrist for pulses too.
Comprehensive Biosensor Platform
Comprehensive biosensor platform is a lightweight, dry-fit, comfortable shirt with add-on, conformal sensor “islands” that enable remote physiological monitoring without compromising performance, looks, or launderability. Digital sensors include temperature, ECG, respiratory rate and accelerometer (plus additional calculated metrics) as well as sensor islands to monitor biochemical markers and biodynamic influences.
Senno – The Balance Ring
Senno uses noninvasive hyperspectral measurement and it measures the user's life 24/7 – if desired. With this information, that is displayed at the phone app or a web browser, the user can balance her/his life by choosing the right diet or party like an animal in the nightclub.
OneDraw Blood Collection Device
OneDraw Blood Collection Device (BCD) enables remote collection and stabilization of dry capillary blood which can be used for accurate COVID-19 antibody testing and surveillance. It allows for remote sample collection in a convenient, comfortable way and improves patient care by facilitating blood collection into the home setting.
Miniaturized and Portable fNIRS based Brain Monitoring System
Our goal is to develop miniaturized and portable Time Domain functional Near Infrared Spectroscopy system that can be used for many applications in research such as the study of neurovascular coupling, the characterization of brain activity during specific tasks/sensori stimuli and more recently brain computer interface applications.
Curate™ Cell Processing System
Curate™ provides a step-change in manufacturing cell therapies, with a groundbreaking microfluidic cell isolation/processing solution that delivers more and higher-quality patient-sourced cells more consistently, with lower operator-skill requirements. The system dramatically reduces cell therapy manufacturing time/cost, can be robustly deployed for non clean-room use, and is scalable.
Low-Cost, Anti-viral Active Air-Purifying Respirator with Bio-microreactor to Defend Against Pathogenic Attack Including SARS-CoV-2
Out Innovation is a respiratory protective full-face active breathing mask integrated with propitiatory bio-microreactor to neutralize pathogens that provide, respiratory protection from airborne contaminants such as dust, fumes, smoke, mists and especially against from microorganisms, including bacteria and viruses. It is lightweight and ensures comfortability in respiration for prolonged use.
Therapeutic inhibitor for Epstein-Barr virus (EBV)-associated cancers with responsive optical imaging function
EBV nuclear antigen 1 (EBNA1) is the only viral protein expressed in all EBV-infected cancer cells, and it maintains the survival of these cancer cells. Our EBNA1 inhibitor can specifically target EBNA1 in cancer cells and provides a safe and effective method for treatment and imaging of EBV-associated cancers.
Aspire™ AI Mobile Elderly Fall Risk Assessment by BooGuu Co Ltd.
A wearable solution to reduce elderly fall risk by assessing critical risk factors in 5 minutes, including balance, mobility, gait irregularity, and lower limb strengths. Patented AI algorithms provide risk assessment information to better enable medical professionals in minimizing fall risks with optimum recommendation and follow-up actions.
Microlyte® Antibiofilm Wound Matrix
Ultrathin bioresorbable matrix to combat local pain and infections in trauma wounds. Silver and gallium ions in the matrix work synergistically to kill bacteria hidden in biofilms on a wound surface. Matrix provides template for cell growth and accelerates wound closure.
San Jose, CA
The 90+% clinical trial failure for new drugs is mostly due to poorly selected targets. With 20,400+ genes, but over 1 million proteins, the difference is accounted by their significant, newly recognized complexity. Our technology is designed from the start to provide accurate targets with their inherent complexity in mind.
Soft, flexible and Scalable Circuits for Textile Applications
Circuit boards power the world, but are built for hard goods. LOOMIA makes a new form-factor of circuit - a soft circuit system- that can be used to power soft goods. Our patented technology can be used to design reliable heaters, lighting systems and sensing systems within textile substrates.
Full Spectrum mPrep System for Field and Clinic Preservation and Rapid Preparation of Biospecimens for Clinical Diagnostics and Pathogen Threat Analysis
The Full-Spectrum System enables safe and reliable collection and preservation of potential biothreats (natural, biowarfare), and ordinary clinical or research biospecimens, even in field environments. The System then provides safer, faster and easier biospecimen preparation required for microscope analysis. The System thus enables rapid understanding of biothreats and faster diagnoses.
The Advanced Microphysiological Brain Injury Technology (AMBIT) Platform
The Advanced Microphysiological Brain Injury Technology (AMBIT) Platform is an organ-on-chip model capable of recapitulating pathophysiologies of brain injury through mechanical stimulation. The fundamental unit is a blood-brain barrier platform that be employed for drug screening and toxicity studies.
Ultra-high performance wearable thermoelectric coolers with less materials
Our ultra-high performance wearable thermoelectric cooler can cool human-skin by up to 8.2°C below ambient temperature under normal conditions. This is around 170% higher cooling than commercial modules. Notably, we use 2-3 times less thermoelectric material than commercial modules, providing a cost-effective, lightweight, and practical solution for localized human-body cooling.
SVETEX: Ultra cooling uniform apparel based on, patent protected, smart polyethylene (PE) fibers and fabrics.
NERAMCO offers SVETEX, a novel (MIT-developed) polyethylene (PE) fiber demonstrated and woven/knitted into fabric, SVETEX. SVETEX allow the human body to cool via thermal radiation and offer a high-performance sustainable alternative to conventional textiles extending beyond passive thermoregulation. Svetex is: ultralight weight, low material cost, low carbon/environmental footprint, quick dry/wash.
Novel therapeutic for treatment of INOCA (Ischemia with No Obstructive Coronary Artery disease) and coronary micro-vascular disease
A novel therapeutic for the treatment of chronic heart failure – coronary-specific vasodilator to prevent the microvascular dysfunction responsible for heart failure.
Digital Device to Objectively Measure Pain
PainQx is an AI-powered medical device company that has developed a method to objectively measure chronic pain. The PainQx platform analyzes neural activity from a patient’s EEG and processes the data through proprietary machine-learning algorithms. Our software outputs a scaled chronic pain biomarker correlating to a patient’s chronic pain state.
A non-invasive hypertension therapy device and a migraine and headache therapy device.
The PhysioCue hypertension therapy Device uses the cold temperature and micro-vibration therapy, applied to the carotid sinus for 5 minutes daily, to significantly lower blood pressure. PhysioCue's therapy devices are efficient, safe, easy to use, user's friendly devices and has none of the side effects associated with drugs.
A Health Indicator for Viral Infection
We propose a biosensor for detecting the presence of virus particles in respiratory droplets emitted from the breath of a subject. The dime-sized biosensor is attached in the interior of a facemask worn by an individual, collects respiratory droplets, and indicates whether the individual is infected with a virus.
Smart 3D Knit Physiological Sensing Base Layer
Propel’s Smart 3D Knit physiological sensing base layer is wearable, comfortable and washable. High quality heart rate data is collected by any data module for remote transmission and monitoring. The smart garment can be easily customized e.g. fire resistant, and is designed for transition to manufacturing.
Targeted alpha-emitter therapy of neuroendocrine tumors
AlphaMedix (TM) is a highly selective and effective drug tagged with an alpha-emitter for therapy of neuroendocrine tumors. Our company received an orphan drug designation for this drug and has a pending patent (PCT stage) for the composition, kit, and the method of AlphaMedix preparation.
Miniature Remote Physiological Status Monitoring Platform
All key vitals remotely monitored at once in real-time continuously by Sempulse's award winning non-invasive, miniature, wireless platform that is easily placed behind the ear to acquire the 5 major vital signs – Cuffless Blood Pressure, Pulse Oximetry, Heart Rate, Respiratory Rate, and Body Temperature.
SafeGuard: An Intelligent Health, Safety, and Performance Monitoring Platform
SafeGuard™ is an intelligent health and safety management platform providing enhanced awareness via real-time monitoring of personnel working in high-risk occupations. SafeGuard™ uses cloud and edge computing, secure communication protocols, and cutting-edge wearable sensors to collect data including environmental conditions, operational context, and worker physiology, location, and posture.
Turnkey Solar Nanogrids for DriveUp Covid-19 Testing
Sesame Solar has developed a mobile, complete, ready-to-go, Solar Nanogrid for DriveUp Covid-19 Testing that includes: solar power generation/storage, water generation, antimicrobial lights, toilet/sink/sanitizing areas, refrigerator, WiFI/communications, PPE, Covid-19 Test Kits/Processing systems, interviewing/scheduling software/portal, that can be towed anywhere behind a 3/4 ton truck carrying 2-4 medical technicians.
Shield-X BX-C Skullcap and Shield-X BX-R Helmet Cover
Current helmet design does not adequately reduce the sharp twisting of the brain that results in concussion/traumatic brain injury from a sharp blow to the head. SXT’s two alternative patent protected products (a skullcap or a helmet cover) significantly enhance helmet performance without requiring the redesign of a helmet.
Biological Vital Sensor made from Carbon Nanotube Yarn, wearable and washable .
The CNT yarn sensor continuously monitors vital signs. Although it is, at present, possible to monitor those signals at hospital only, the new sensor can allow us diagnosis check through the WEB for 24 hours. It realizes a true e-hospital.
Pandemic Response Optical Biosensing Engine (PROBE)
PROBE is a portable, handheld sensing platform that can deliver highly sensitive, rapid results for a range of tests (COVID-19, influenza, sepsis, etc.) without the need for expensive equipment, laboratories, or skilled medical personnel.
Compact NMR Device for Fingertip Assessment of Metabolic Health and Diabetes Risk
This invention is used to screen for early metabolic syndrome (EMS), a precursor to type 2 diabetes and cardiovascular disease. this is achieved by using nuclear magnetic resonance (NMR) relaxometry.This scan takes under minute, is non-invasive, and can be used to pre-screen patients for early detection.
Rapid COVID and Viral Detection Sensor
This invention enables the rapid detection (within seconds) of virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2), Human Immunodeficiency Virus (HIV), and other pandemic viruses. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, or at home.
Chitosan medical& health textile solution
Chitosan is a material that can be obtained from the shells of crabs and shrimps. Our technology enables chitosan mixed in final products in form of fiber, yarn, net, paper and fabric. They can be applied to multiple end-use such as daily wear, protective wear, interior, furniture, vehicle, filtration and construction.
Posture Training Bodywear for Older Adults with Degenerative Scoliosis
To treat patients with adult degenerative scoliosis, a posture training bodywear is designed to maintain patients’ level of bodily function while minimizing symptom progression; notably, 3D printable materials and notification sensors are strategically applied onto the bodywear for support towards body alignment and pain management of the patients.
Nanocomposite fibrous membrane as artificial periosteum
We develop an artificial periosteum made of electrospun nanocomposite fibrous membrane consisting of photocrosslinkable gelatin and hydroxyapatite nanoparticles which can crosslink with each other upon light exposure. Our artificial periosteum boasts strong bone tissue adhesion, excellent biocompatibility and tunable mechanical properties. It has substantially enhanced bone and blood vessel regeneration.
Photocrosslinkable nanocomposite ink for printing of strong, biodegradable and bioactive bone graft
We successfully synthesize a fast-curing photocrosslinkable nanocomposite bone ink composed of triblock polymer and functionalized hydroxyapatite nanoparticles, and 3D print the bone ink into bone grafts with complex architecture, strong mechanical property, controllable degradability, effective biomolecule encapsulation and release, and excellent performance to promote bone regeneration.
PolyUStimulator – Ultrasound Driven Piezoelectric Stimulator for Neuromusculoskeletal Rehabilitation
Electrical stimulator such as cardiac pacemaker and deep brain stimulator cures numerous health conditions and is a gold standard treatment in rehabilitation. Current electrical stimulators, are however bulky and require a major surgery to implant. To address this problem, we have developed a tiny injectable stimulator, called PolyUStimulator.
MOVES® SLC™ is a portable, completely integrated multi-capability life support system which combines the functions of an oxygen conserving ventilator, an oxygen concentrator, suction, and complete vital signs monitoring. It is a platform agnostic solution for patient care in austere environments, intended to supply a complete continuum of care solution
Technology for accelerated development of potent, thermostable, inactivated vaccines for emergent diseases
This innovative technology platform offers an accelerated approach for rapid development and production of thermostable and potent vaccines against potentially pandemic viral outbreaks. It is done by performing electron beam (EB) inactivation of wild-type virus immobilized in a carbohydrate glass through use of Preservation by Vaporization (PBV).
Autograft extracting device for autologous osteochondral transplantation
A bone and/or cartilage removal device to harvest a precisely defined autologous graft for mosaicplasty, a technique in which bone and cartilage ('osteochondral') lesions are repaired by harvesting and transplanting cylindrical plugs of bone and cartilage.
Cost Effective Preparation of Highly Stable, Reusable Whole Cell Biocatalysts
Cost effective enzyme stabilization and delivery - a method to create microbial exoskeleton that enhances the overall performance and stability of whole cell biocatalysts.
Enhancing non-invasive brain stimulation treatment with customized 3D skull prints
Non-invasive brain stimulation has already shown improvements in depression, pain and cognitive problems. However, the precise location of stimulation site is difficult to obtain, especially if this is to be used in-home with a commercial device. Our innovation will close these gaps and enhance use of this therapy remotely.
VaxCelerate is a Self-Assembling Vaccine platform addresses the need for rapid vaccine development by creating a platform capable of making and initially testing a new vaccine against specific, as yet unknown, pathogens and emerging infectious diseases such as COVID-19 in less than 120 days. This would protect warfighters from contracting emerging infectious diseases.
Slippery Anti-Fouling Coatings on Flexible Catheters
This technology allows a new class of Slippery Liquid-Infused Porous Surfaces (SLIPS) to be deposited onto challenging surfaces, such as catheters and other flexible tubes, to prevent microbial colonization. The SLIPS coatings can reduce systemic infections and biofilm formation caused by pathogens in indwelling catheters.
Minimally invasive microwave ablation antenna for targeted cancer treatment
This antenna allows for faster, highly-targeted, minimally-invasive tumor removal via microwave ablation. The unique balun-free antenna design allows for more targeted tumor ablation with less unwanted damage to surrounding tissue. This thinner, more flexible antenna also offers the potential for less invasive intravascular ablation procedures not possible with commercially-available alternatives.