Drug delivery beyond PEGylation

S. Jiang
Cornell University,
United States

Keywords: zwitterionic materials, poly(ethylene glycol) (PEG), immunogenicity, vaccines

Summary:

An important challenge in many applications is the prevention of unwanted nonspecific biomolecular and macromolecular attachment on surfaces or nanoparticles from medical implants to drug delivery carriers. We have demonstrated that zwitterionic materials and surfaces are highly resistant to nonspecific protein adsorption and microorganism attachment from complex media. Typical zwitterionic materials include poly(carboxybetaine), poly(sulfobetaine), poly(trimethylamine N-oxide), and glutamic acid (E) and lysine (K)-containing poly(peptides). Unlike poly(ethylene glycol) (PEG), there exist diversified zwitterionic molecular structures to accommodate various properties and applications. Furthermore, unlike amphiphilic PEG, zwitterionic materials are super-hydrophilic. In this talk, I highlight the applications of zwitterionic materials the development of nanocarriers for the delivery of small molecules, proteins, mRNA and DNAs. I will also discuss recent studies on the development of low immunogenic and targeted mRNA/LNP cancer vaccines.