Nature-inspired nanoparticles for gene and vaccine delivery

H. Song
The University of Queensland,

Keywords: nanoparticles, silica, DNA delivery, vaccine delivery


Recent advances in nanotechnology have greatly boosted the development of novel delivery systems for therapeutic and vaccine applications. To lead a successful nanomedicine technology, the key lies in the rational design and fabrication of safe and efficient nano-carries, while the delivery performance could be maximized by custom-designed nanoparticles considering the unique bio-interface configurations towards both cargo biomolecules and cell/tissue surfaces. Mimicking the spiky morphology of pollen and virus, which allowed enhanced interactions at bio-interfaces, here, we showcase our recent progress in the development of spiky nanoparticle-based smart theranostics.[1-4] Through a simple sol-gel synthesis approach, colloidal nanoparticles with an intrinsic spiky surface are fabricated and characterized by the advanced microscopy techniques of electron tomography.[5] We demonstrated the precise control over the delicate nanotopography, engineering the surface chemistry,[6] hollow interior,[7] and asymmetry of the particles.[8] We explored the interactions of these unique spiky nano-features towards both biomolecules and cells, underpinning the development of 1) a bacterial-adhesive antimicrobial nano-agent,[1, 9-11] featuring an antibiotic-free approach to address the drug-resistance issue; 2) a DNA/mRNA hooking strategy for efficient intracellular delivery[12]; 3) a pathogen mimetic adjuvant that boosts the vaccine delivery performance[3]. From bench to market, this spiky nanoparticle-based delivery platform is on the translation collaborated with industrial partners toward novel nanomedicine. Our journey from fundamental research to the launching of ‘NUVEC®’ will also be shared in this talk. [1] H. Song, Y. A. Nor, M. H. Yu, Y. N. Yang, J. Zhang, H. W. Zhang, C. Xu, N. Mitter, C. Z. Yu*. J Am Chem Soc 2016, 138, 6455. [2] H. Song, M. H. Yu, Y. Lu, Z. Y. Gu, Y. N. Yang, M. Zhang, J. Y. Fu, C. Z. Yu*. J Am Chem Soc 2017, 139, 18247. [3] H. Song, Y. Yang,* J. Tang, Z. Gu, M. Zhang, C. Yu*. Adv Therapeutics 2020, 3, 1900154. [4] D. Cheng, J. Zhang, J. Fu, H. Song*, C. Yu*. Sci Adv 2023, 9, eadi7502 [5] H. Song, Y. Yang, J. Geng, Z. Gu, J. Zou,* C. Yu*. Adv Mater 2019, 38, 1801564. [6] J. Geng, H. Song,* F. Gao, Y. Kong, J. Fu, J. Luo, Y. Yang,*C. Yu. J Mater Chem B 2020, 8, 4593. [7] E. Hines, D. Cheng, W. Wu, M. Yu, C. Xu, H. Song,* C. Yu.* J Mater Sci 2021, 56: 5830. [8] X. Lin, W. Wu, J. Fu, Y. Yang, B. Guo, C. Yu,* H. Song*. ACS Appl Mater Interfaces 2021, 13: 50695. [9] B. Li, Y. Liao, X. Su, S. Chen, X. Wang, B. Shen, H. Song*, P. Yue*. J Nanobiotech 2023, 21: 325. [10] M. Zhang, J. Feng, Y. Zhong, J. Luo, Y. Zhao, Y. Yang, Y. Song, X. Lin, Y. Yang,* H. Song,* C. Yu.* Chem Eng J 2022, 440: 125837. [11] Y. Wang, Y. Yang, Y. Shi, H. Song,* C. Yu* Adv Mater 2020, 32: 1904106. [12] B. Sun, W. Wu, E. Narasipura, Y. Ma, O. Fenton,* H. Song.* Adv Drug Del Rev 2023, 200: 115042.