Dr. Simona Patange is a Biologist with the NIST Material Measurement Laboratory, Biosystems and Biomaterials Division. She coordinates projects on cell-based specificity measurements for the NIST Genome Editing Program and NIST Genome Editing Consortium. Her current research focuses on quantitative single-cell metrics to characterize the on- and off- target activity of CRISPR/Cas genome editing systems. Dr. Patange additionally serves as co-organizer of the NIH Light Microscopy Interest Group (LMIG), which brings visibility to innovative microscopy techniques that utilize single-cell imaging and in-situ biophysics for applications to biomedical research.
Dr. Patange received her Ph.D. in Biophysics from the University of Maryland in 2020. Her doctoral research was a collaboration between the UMD Dept. of Physics and the National Institutes of Health through the NCI-UMD Partnership for Integrative Cancer Research. Her dissertation utilized optogenetic engineering and quantitative single-cell microscopy to determine how the c-MYC oncogene acts as a global amplifier of gene expression in human cells.