G.J. Colmenares Roldán, L.M. Agudelo Gomez, I.C. Ortiz, L.M. Hoyos Palacio
Keywords: nanoparticles, hydroxyapatite, bioabsorbable nanocomposite
Summary:The present work describes all the trials, methodologies and results that allowed to obtain a bioabsorbable nanocomposite of PLGA-HA with possible biomedical applications. First, hydroxyapatite nanoparticles (HA) were synthesized using the microwave-assisted hydrothermal synthesis technique, for which two precursor solutions were prepared, the first one of 0.024 M potassium phosphate and the second of 0.04 M calcium nitrate, these were mixed with different concentrations of surfactants (CTAB and Pluronic F-127) to identify the effect of these on the size and morphology of the nanoparticles. The nanoparticles obtained were characterized by SEM and the images analyzed with the Image J software to determine the approximate size of the particles. The smallest HA particles obtained were those synthesized with CTAB at a concentration of 0.001M (190 34 nm), which did not present contaminants and a crystallinity according to the reports in the literature according to the results of EDX, FTIR and XRD. Additionally, the cytotoxicity presented by the HA particles was low. Subsequently, said nanoparticles were used to reinforce the PLGA 85:15 polymer (Resomer LG 857S) with 1%, 2%, and 5% HA, forming the composite materials. These materials were characterized by micro and nanoscale roughness, as well as Young's hardness and modulus using the AFM indentation technique. Finding that the nanocomposite with 2% HA had the greatest increase in Young's modulus 38.5% (2.956 GPa).