Nanoparticles of hydroxide and magnesium oxide: formation of PLGA nanocomposite and possible biomedical application

G.J. Colmenares, L.M. Agudelo, M. Londoño, S. Mesa, F. Jaramillo, I.C. Ortiz, L.M. Hoyos Palacio

Keywords: sol-gel, nanoparticles, magnesium oxide, magnesium hydroxide, nanocomposite, PLGA, reinforcement


This paper describes the methodology to produce magnesium oxide and hydroxide nanoparticles by the traditional sol-gel methodology and a new methodology using a nanoprecipitation system previously developed by the Systems Biology Research Group to produce polymeric nanoparticles (Colmenares-Roldan et al. 2018; Colmenares Roldán et al. 2018). The nanoparticles obtained were characterized by TEM, FTIR, and XRD. This paper also shows the evaluation of the nanoparticles developed in the reinforcement of PLGA 85:15 (Resomer LG 857S), using three levels of nanoparticles, and the samples were characterized by AFM to determine the variations in the Young modulus and the hardness using the Oliver-Pharr model. The magnesium hydroxide particles at 1%, 2%, and 5% increased the modulus of the material by 37.8%, 26.7%, and 14.4% respectively with respect to the non-reinforcing polymer, and the magnesium oxide particles at 1%, 2%, and 5% significantly increased the material module by 36.8%, 36.8%, and 55.8% respectively. Additionally, biological safety evaluations were carried out on the materials obtained, determining their cytotoxicity, genotoxicity, and mutagenicity to define future biomedical applications.