Drug nano-conjugates with 2D-carbonic materials shows anti-proliferation response with human hepatic carcinoma cells

V. Agrawal, M. Dhayal
Indian Institute of Technology (BHU) Varanasi,
India

Keywords: graphene, nanocomposites, drug release

Summary:

We report a process for the synthesis of drug conjugated 2D-carbonic materials from graphene family and reduced graphene oxide (rGO) by incubation, oxidation and controlled reduction of pristine graphite material. The characterization of the material was confirmed by Raman spectra with D and G band peaks at 1351 cm-1 and 1579 cm-1. The structured layer configuration of the GO and rGO was characterized using TEM imaging having 100-1000 nano-assemblies. The drug conjugated 2D-carbonic material showed an increased potential as a drug carrier to the cancer cells. As a model system we have tested these nanoconjugates with hepatic carcinoma cells and cell viability and proliferation in comparison to the original drug were assessed. The study has been performed for optimising kinetics of drug dose and subsequently, its potential for relative reduction in requires does of free drugs towards limiting cancer cell proliferation.