Washington State University, Pullman, WA, US
The mammalian extracellular matrix (ECM) is comprised of a labyrinth of interconnected architecture that provides mechanical support and optimal tissue microenvironment for cell survival, growth, signal transduction and interactions. The currently available scaffold and planar tissue culture models using synthetic polymers or a single component of ECM do not resemble this native living microenvironment. Therapeutic studies and preclinical applications based on these methods have failed to provide consistent data and acceptable efficacies. In addition, post-degradation toxicity caused by the polymeric scaffolds disrupts cell-to-cell signaling, leading to defects in secretion of biomolecules/enzymes, rejection of scaffold graft, cell death and severe side effects. These factors necessitate a “next-generation” of scaffold system that resembles native ECM for reliable scientific research, drug testing and tissue regeneration studies.In order to address the above problems, WSU has developed Tissue Matrix Scaffold (TMS), a versatile 3D matrix, which is an intermediate platform between 2D culture models and more complex and expensive in vivo models. The decellularized TMS retains the structural and compositional nature of ECM, making it well suited for both scientific research and clinical applications.
Primary Application Area: Biotech, Pharma, Medical Devices
Technology Development Status: Prototype
Technology Readiness Level: TRL 4
Vetted Programs/Awards: Science Advances Journal: http://advances.sciencemag.org/content/3/9/e1700764.full.
Organization Type: Academic/Gov Lab
Showcase Booth #: 35T
GOVT/EXTERNAL FUNDING SOURCES
External Funding to Date: WSU Commercialization Gap Fund