Materials for Drug & Gene Delivery

Symposium Co-Chairs

Steven Zullo
Program Officer, Extramural Science Program, OPESP
NIBIB/NIH

Thomas Anchordoquy
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences
University of Colorado School of Pharmacy

Key Speakers

Old Drugs in New Wraps
Shanta Dhar
Department of Biochemistry and Molecular Biology
Sylvester Comprehensive Cancer Center
Miller School of Medicine
University of Miami, USA

Robust in vivo gene editing in mouse hepatocytes with systemic lipid nanoparticle delivery of CRISPR/Cas9 components
Kristy Wood
Senior Director, Non-Viral Delivery, Intellia Therapeutics, Inc.

Seek, Destroy and Heal: Enzyme-Responsive Nanoparticles as In Vivo Targeted Delivery System
Nathan Gianneschi
Associate Professor of Chemistry and Biochemistry, University of California, San Diego

David Rampulla
Program Director, Division of Discovery Science & Technology
U.S. National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Propagation of Cell Death Programs in Cancer Using Targeted Ultrasmall Silica Nanoparticles
Michelle Bradbury
Associate Professor, Memorial Sloan Kettering Cancer Center, Elucida Oncology, Inc

Recombinant Polymers for Drug and Gene Delivery
Hamid Ghandehari
Professor, Director of Utah Center for Nanomedicine, University of Utah

Echogenic Nanobubbles: New opportunities for ultrasound-enhanced drug delivery for cancer therapy
Agata Exner
Professor of Radiology and Biomedical Engineering, Case Western Reserve University

Symposium Sessions
	Monday May 15
1:30	Biomed Innovation Spotlights: Medtronic, GE Healthcare
	Tuesday May 16
10:30	Nanoparticle Drug Delivery and Nucleic Acids
1:30	Imaging & Drug Delivery, Theranostics
	Wednesday May 17
8:30	The Future of Drug & Gene Delivery: Panel Discussion
10:30	Intracellular & Organelle Delivery
1:30	Peptides, Proteins, & Viral-assisted Drug Delivery
	Materials for Drug & Gene Delivery: Posters

Symposium Program
	Monday May 15

1:30	Biomed Innovation Spotlights: Medtronic, GE Healthcare	National Harbor 12
	Session chair: Conrad Clyburn, MedForeSight, US
1:30	Medtronic: Innovation Spotlights N. Virag, Medtronic, US
1:45	GE Healthcare: Innovation Spotlights M. Brown, GE Healthcare, US
2:00	Nanobiomimetic reagent-free sensing and energy storage E. Chen, Advanced Biomimetic Sensors, Inc., US
2:07	Aereus Shield Antimicrobial Copper Alloy Coating D. Anonychuk, Aereus Technologies Inc, CA
2:14	Point-of-Care Micro Biochip for Cancer Diagnostics E.S. Lee, New Jersey Institute of Technology, US
2:21	Rijuven Patient Care Platform T. Silecky, Rijuven Corporation, US
2:28	Highly Stretchable Electronic Tactile Sensors L. Dobis, University of California, Santa Barbara Office of Technology & Industry Alliances, US
2:35	Polymers for the capture of volatile anaesthetics T. Spencer, University of Melbourne, AU
2:42	Integrated Photonic Devices for ultrahigh-speed, space-division multiplexing optical coherence tomography C. Zhou, Lehigh University, US
2:49	Novel Therapy for Bone Regeneration F. Safadi, Northeast Ohio Medical University, US
2:56	Medtronic, GE Healthcare: Q&A
	Tuesday May 16

10:30	Nanoparticle Drug Delivery and Nucleic Acids	Chesapeake 8-9
	Session chair: Steven Zullo, NIBIB/NIH, US; Thomas Anchordoquy, University of Colorado, US
10:30	Robust in vivo gene editing in mouse hepatocytes with systemic lipid nanoparticle delivery of CRISPR/Cas9 components (invited presentation) K. Wood, Intellia Therapeutics, US
10:55	Programmable Formation of Quantum Dot Lattices with Applications in Biosensing and conditional RNAi Activation K. Afonin, M. Jones, University of North Carolina, Charlotte, US
11:15	Role of microRNA-205 in Gemcitabine Resistant Pancreatic Cancer R.I. Mahato, A.K. Chaudhary, G. Mondal, V. Kumar, K. Kattel, D. Chitkara, A. Mittal, University of Nebraska Medical Center, US
11:35	Continuous Production of Polymer Coated Drug Crystals, Particles and Nanoparticles by Hollow Fiber Membrane-based Cooling Crystallization and Anti-solvent Crystallization, vol. 3: pp. 52-55 K. Sirkar, D. Chen, D. Singh, C. Jin, R. Pfeffer, New Jersey Institute of Technology, US

1:30	Imaging & Drug Delivery, Theranostics	Chesapeake 8-9
	Session chair: Steven Zullo, NIBIB/NIH, US; Thomas Anchordoquy, University of Colorado, US
1:30	Propagation of Cell Death Programs in Cancer Using Targeted Ultrasmall Silica Nanoparticles (invited presentation) S.E. Kim, L. Zhang, K.M.M. Riegman, F. Chen, S. Monette, T. Quinn, U. Wiesner, M. Overholtzer, and M.S. Bradbury, Memorial Sloan Kettering Cancer Center, US
1:55	Echogenic Nanobubbles: New opportunities for ultrasound-enhanced drug delivery for cancer therapy (invited presentation) A. Exner, Case Western Reserve University, US
2:20	Modulation of Doxorubicin Toxicity Through Nanoparticle-assisted Cellular Delivery A. Sangtani, E. Petryayeva, M. Wu, K. Susumu, E. Oh, A.L. Huston, G. Lasarte-Aragonés, I.L. Medintz, W.R. Algar, J.B. Delehanty, US Naval Research Laboratory, US
2:40	Amphiphile Self-Assembly Theranostic Materials for Drug Delivery and Medical Imaging C.J. Drummond, X. Mulet, C.E. Conn, C. Fong, M. Moghaddam, S.M. Sagnella, X.J. Gong, J. Zhai, RMIT University, AU
3:00	Nano-magnetically targeted drug delivery system for treating Atrial Fibrillation (AF), vol. 3: pp. 64-66 A. Harel, NanoMed Targeting Systems Inc., US
3:20	Drug and Gene Delivery Programs at the National Institute of Biomedical Imaging and Bioengineering (invited presentation) D. Rampulla, US National Institute for Biomedical Imaging and Bioengineering (NIBIB), US
	Wednesday May 17

8:30	The Future of Drug & Gene Delivery: Panel Discussion	National Harbor 3
	Session chair: Steven Zullo, NIBIB/NIH, US
	N. Gianneschi, UCSD, US
	K. Wood, Intellia Therapeutics, Inc., US
	M. Bradbury, Memorial Sloan Kettering Cancer Center, US
	H. Ghandehari, University of Utah, US
	A. Exner, Case Western Reserve University, US
	T. Anchordoquy, University of Colorado School of Pharmacy, US

10:30	Intracellular & Organelle Delivery	Potomac 5
	Session chair: Steven Zullo, NIBIB/NIH, US; Thomas Anchordoquy, University of Colorado, US
10:30	Old Drugs in New Wraps (invited presentation) S. Dhar, University of Miami, US
10:55	Bilayer coated ureteral stent as drug delivery platform to treat ureteric diseases, vol. 3: pp. 87-90 W. Lim, G.M. Xiong, T.W. Chong, Y. Huang, S. Venkatraman, Nanyang Technological University, SG
11:15	An Integrated Biometric Platform for Evaluation of Targeted Drug Delivery Y. Liu, Lehigh University, US
11:35	DEVELOPMENT OF SUSTAIN RELEASE POVIDONE IODINE OPHTHALMIC DROP THROUGH NOVEL IN-SITU GEL FORMULATION, vol. 3: pp. 91-94 G. Wei, X. Gao, X. Li, Y. Lu, J.J. Baldwin, B. Liang, IVIEW Therapeutics Inc., US
11:55	Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis, vol. 3: pp. 67-70 B. Polyak, Drexel University, US

1:30	Peptides, Proteins, & Viral-assisted Drug Delivery	Potomac 5
	Session chair: Steven Zullo, NIBIB/NIH, US; Thomas Anchordoquy, University of Colorado School, US
1:30	Recombinant polymers for drug and gene delivery (invited presentation) H. Ghandehari, University of Utah, US
1:55	Seek, Destroy and Heal: Enzyme-Responsive Nanoparticles as In Vivo Targeted Delivery System (invited presentation) N. Gianneschi, University of California, San Diego, US
2:20	Self-navigating drug delivery nanovehicles driven by polyvalent multifunctional phages and their promiscuous proteins, vol. 3: pp. 134-137 V.A. Petrenko, J.W. Gillespie, Auburn University, US
2:40	Platform Reagent Development for the Intracellular Delivery of Therapeutic Peptides, vol. 3: pp. 56-59 B.C. Evans, C. Lander, C.L. Duvall, Moerae Matrix, Inc., US
3:00	Molecular toolkits for engineering of self-navigating drug delivery vehicles, vol. 3: pp. 44-47 J.W. Gillespie and V.A. Petrenko, Auburn University, US
3:20	Nanodelivery of cerebrolysin reduces depressive stress induced exacerbation of Alzheimer’s disease brain pathology following amyloid-beta peptide infusion, vol. 3: pp. 71-74 H.S. Sharma, D.F. Muresanu, J.V. Lafuente, R. Patnaik, Z.R. Tian, A. Ozkizilcik, R.J. Castellani, H. Mössler, A. Sharma, Uppsala University, SE

	Materials for Drug & Gene Delivery: Posters	Potomac Registration Hall
	Novel Nano-biomaterials for Inhibition of Respiratory Syncytial Virus, vol. 3: pp. 75-78 S. Joshi, D. Kirby, Y. Perrie, S.R. Singh, Alabama State University, US
	PLGA Nanocapsules Inside of Collagen Nanofibers for Release of Paclitaxel as Agent of Control the Restenosis in Drug Eluting Stents L. Agudelo, G. Colmenares, R. Pinal, L. Hoyos, Universidad Pontificia Bolivariana, CO
	Site-Specific Albumination for the Enhanced Serum Half-Life In Vivo I. Kwon, Gwangju Institute of Science and Technology, KR
	In vitro targeting behaviors of Folate-conjugate Pluronic F127/poly (lactic-co-glycolic) nanoparticles X.Y. Xiong, Jiangxi Science and Technology Normal University, CN
	miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application, vol. 3: pp. 95-98 A. Montgomery, S. Bawage, A. Chaudhary, S.R. Singh, K. Vig, Alabama State University, US
	Sustained Release of Functional Interleukin-10 Encapsulated within Poly (lactic acid)-b-Poly (ethylene glycol) Nanoparticles Down-regulates Cytokines in Mouse Macrophages Exposed to Chlamydia trachomatis, vol. 1: pp. 118-121 S. Duncan, S. Dixit, R. Sahu, E. Nyairo, S.R. Singh, V.A. Dennis, Alabama State University, US
	SERS Detection on GABA absorption with using Modified Gold-chitosan Nanoparticles by MPA B. Wang, I-. Kang, Gachon University, KR
	Physio-structural and immunological characterization of a PLGA 85/15 encapsulated Chlamydia recombinant MOMP nanovaccine candidate, vol. 1: pp. 122-125 R. Sahu, S. Dixit, S.R. Singh, V.A. Dennis, Alabama State University, US
	Alginate/Montmorillonite nancomposites for the delivery of curcumin, vol. 3: pp. 40-43 A.R. Ramadan, M. Ahmed, The American University in Cairo, EG
	Application of a Next Generation Hand Held Antimicrobial Cold Plasma Technology, vol. 3: pp. 99-101 H. Kim, S. Izadjoo, V. Marcel, H. Truong, M. Izadjoo, Trideum Biociences and ChiScan LLC, US
	Neuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke, vol. 3: pp. 79-82 D.F. Muresanu, A. Sharma, J.V. Lafuente, A. Nozari, R. Patnaik, A. Ozkizilcik, Z.R. Tian, H. Mössler, H.S. Sharma, Iuliu Hațieganu University of Medicine and Pharmacy, RO
	TiO2-nanowired delivery of cerebrolysin thwarts exacerbation of sleep deprivation induced decline in regional brain derived neurotrophic factor, brain pathology and behavioral dysfunctions following emotional stress, vol. 3: pp. 83-86 A. Sharma, D.F. Muresanu, J.V. Lafuente, A. Nozari, R. Patnaik, A. Ozkizilcik, Z.R. Tian, H. Mössler, H.S. Sharma, Uppsala University, SE
	Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology, vol. 3: pp. 48-51 A. Sharma, P.K. Menon, D.F. Muresanu, J.V. Lafuente, A. Nozari, R. Patnaik, A. Ozkizilcik, Z.R. Tian, H. Mössler, H.S. Sharma, Uppsala University, SE
	Positively charged Ag-dendron conjugates: Stability enhanced AgNPs for biomedical applications, vol. 3: pp. 102-105 T.J. Cho, J. Liu, V.A. Hackley, National Institute of Standards and Technology, US
	Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo, vol. 3: pp. 60-63 L. Kоbylinska, R. Panchuk, N. Skorohyd, Y. Senkiv, P. Heffeter, W. Berger, N. Boiko, N. Mitina, A. Zaichenko, R. Lesyk, B. Zіmenkovsky, R. Stoika, G.S. Vari, Danylo Halytsky Lviv National Medical University, UA
	Amphiphilic (Lipid-Substituted) Cationic Polymers for siRNA Therapy of Leukemias B. Landry, J. Valencia-Serna, H. Uludag, University of Alberta, CA
	Microfluidics-based Manufacture of PEG-b-PLGA Block Copolymer Nanoparticles for the Delivery of Small Molecule Therapeutics S.M. Garg, M. Parmar, A. Thomas, E. Ouellet, M. DeLeonardis, M. Assadian, A. Armstead, S. Ip, T.J. Leaver, A.W. Wild, R.J. Taylor, E.C. Ramsay, Precision NanoSystems Inc., CA
	Overcoming Manufacturing Challenges For Rapid Development Of Genetic Nanomedicines From Discovery To Scale-Up M. Assadian, A. Armstead, J. Singh, K. Ou, A. Thomas, S.M. Garg, S. Ip, M. Ma, S. Sidhu, T.J. Leaver, A.W. Wild, R.J. Taylor, R. Lockard, E.C. Ramsay, Precision NanoSystems Inc, CA
	Proof of Concept – CRISPR-Cas9 Lipid Nanoparticles as an Efficient Delivery Tool in Primary Neural Cultures M. Assadian, A. Armstead, A. Thomas, R. De Souza, I. Backstorm, A. Brown, E. Ouellet, S. Garg, G. Tharmarajah, K. Marshall, S. Chang, T. Leaver, A. Wild, O. Seira, J. Liu, W. Tetzlaff, Precision NanoSystems Inc, CA

Biocompatible materials with nano-scale structure hold great promise for controlled and targeted delivery and half-life extension of both small-molecule drugs and various classes of biologics, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Promising delivery systems include microcapsules, liposomes, macromolecular conjugates, nanoparticles, dendrimers, and biological stuctures such polypeptides, benign viruses and bacteriophages. This symposium will focus on commercially promising new materials and approaches.