Novel neuroprotective strategies using TiO2 nanodelivery of cerebrolysin and mesenchymal stem cells for the treatment of blast head injury
Blast head injury (BHI) is complex comprising multifactorial forces like, concussive, piercing, explosive and lacerative tissue injuries in soldiers at the battle field. BHI is difficult to treat using available therapies. We found that TiO2 nanodelivery of cerebrolysin with mesenchymal stem cells has superior effects on neuroprotection in BHI.
Molecular Diagnostics for Precision Medicine
Researchers and physicians have long believed that patient genetic information, properly defined and analyzed, could help them to predict which patients are more likely to survive or do better on specific therapeutic regimens instead of throwing everything at them. This is one approach to precision medicine.
Traumatic brain injury induced AlzheimerÃ¢â‚¬â„¢s disease is thwarted by co-administration of nanowired neprilysin and cerebrolysin
Military personnel are vulnerable to traumatic brain injuries (TBI) and AlzheimerÃ¢â‚¬â„¢s disease (AD) as evidences with increased levels amyloid beta peptide in the cerebrospinal fluid and brain parenchyma. We found that co-administration of nanowired neprilysin and cerebrolysin prevented increased AÃŽÂ²P levels in brain thus mitigating AD pathology.
Preventing brain damage by co-administration of nanowired cerebrolysin with TNF-alpha antibodies in concussive head injury following sleep deprivation
Sleep deprivation in military is very common. When concussive head injury occurs in sleep deprived soldiers, the magnitude and intensity of brain damage is enhanced. We found that co-administration of nanowired cerebrolysin with tumor necrosis factor alpha antibodies remarkably reduce brain damage and improve functional recovery.