Materials for Drug & Gene Delivery

Symposium Co-Chairs

Using Cholesterol-based Nanoparticles to Achieve Unprecedented Silencing of Endogenous Genes
Thomas Anchordoquy
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado School of Pharmacy

Confirmed Invited Speakers

Nanobubble Ultrasound Contrast Agents for Cancer Detection and Targeted Drug Delivery
Agata Exner
Professor of Radiology and Biomedical Engineering, Case Western Reserve University

NIH Funding for Novel Drug Delivery Technologies
David Rampulla
Program Director, National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Interplay between nanoparticle coating, complement activation and immune recognition
Dmitri Simberg
Assistant Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado

From black-eyed peas to biology-inspired nanotechnologies
Nicole F. Steinmetz
Mt. Sinai Scholar, Assistant Professor of Biomedical Engineering, Case Western Reserve University

Symposium Sessions
	Tuesday May 24
1:30	Materials for Drug & Gene Delivery: Strategies for Extending Circulation Time
	Wednesday May 25
8:30	Innovation Spotlights: Biotech/Pharma - Integra Life Sciences, Merck
10:30	Materials for Drug & Gene Delivery: Emerging Technologies
1:30	Materials for Drug & Gene Delivery: Promising Novel Approaches
	Materials for Drug & Gene Delivery: Posters 3:30

Symposium Program
	Tuesday May 24

1:30	Materials for Drug & Gene Delivery: Strategies for Extending Circulation Time	Chesapeake 6
	Session chair: Steven Zullo, NIBIB/NIH, Thomas Anchordoquy, University of Colorado School of Pharmacy (bio)
1:30	Polyethylene Glycol Modified Hydroxylated Graphene as Highly Targeted Drug Delivery towards Choroidal Melanoma M. Lin, B. Zhao, S. Jia, L. Yan, W. Zhang, Y. Liu, Wenzhou Medical University, CN
1:50	Novel Biodegradable and pH-sensitive Nanocarriers based on Self-assembling Polypeptides for Active Targeted Drug Delivery L-W Wang, L-H Chen, S. Wu, T-W Wang, National Tsing Hua University, TW
2:10	Questions Surrounding the use of PEGylation for Intracellular Delivery T. Anchordoquy, University of Colorado, School of Pharmacy, US
2:30	'Stealth’ and ‘camouflage’ coatings of plant virus-based nanoparticles (invited presentation) N.F. Steinmetz, A.S. Pitek, S.A. Jameson, F.A. Veliz, Case Western Reserve University, US
2:55	Interplay between nanoparticle coating, complement activation and immune recognition (invited presentation) F. Chen, G. Wang, S. Inturi, D.S. Backos, L.P. Wu, S. Moein Moghimi, D. Simberg, University of Colorado, US
	Wednesday May 25

8:30	Innovation Spotlights: Biotech/Pharma - Integra Life Sciences, Merck	National Harbor 4
	Session chair: S. Kubisen, The George Washington University, US
8:30	Integra Life Scienses: Innovation Spotlights T. Twardowski, Integra, US
8:45	Merck: Innovation Spotlights M. Lamm, Merck, US
9:00	Co-administration of nanowired Alpha-melanocyte stimulating hormone and cerebrolysin enhances neuroprotection in concussive head injury following sleep deprivation A. Sharma, Uppsala University, SE
9:07	Novel Purification Method for Membrane Proteins L. Loev, Ariel University R&D Co., Ltd., IL
9:14	Design and Scalable Biosynthesis of Acid-Tolerant Enzymes as Broad-Spectrum, Biocompatible Disinfectants B. Berger, Lehigh University, US
9:21	Anchored Immersion Microplate Lids for 3D Cell Culture A. Lyons, ARL Designs LLC, US
9:28	Antimicrobial technology A. Agrawal, Agienic Inc, US
9:35	Overcoming antibiotic resistance through a novel mechanism of action M. Thomas, Agile Sciences, US
9:42	Integra, Merck Q&A

10:30	Materials for Drug & Gene Delivery: Emerging Technologies	Potomac 5
	Session chair: Steven Zullo, NIBIB/NIH, Thomas Anchordoquy, University of Colorado School of Pharmacy (bio)
10:30	Plant virus-like particle-based cancer immunotherapy N.F. Steinmetz, S. Fiering, P. Lizotte, A.M. Wen, Case Western Reserve University, US
10:50	Nanobubble Ultrasound Contrast Agents for Cancer Detection and Targeted Drug Delivery (invited presentation) A. Exner, Case Western Reserve University, US
11:15	Nanostructured lipid carriers as delivery systems of chemically grafted protein antigens E. Bayon, J. Morlieras, T. Courant, A. Gonon, P. Marche, F. Navarro, CEA, FR
11:35	Translational Research of Hemoglobin-vesicles as a Transfusion Alternative H. Sakai, Nara Medical University, JP
11:55	X-act Nanogels: A Robust Nanotechnology Platform for Drug Delivery S. Thayumanavan, University of Massachusetts Amherst, US

1:30	Materials for Drug & Gene Delivery: Promising Novel Approaches	Potomac 5
	Session chair: Steven Zullo, NIBIB/NIH, Thomas Anchordoquy, University of Colorado School of Pharmacy (bio)
1:30	NIH Funding for Novel Drug Delivery Technologies (invited presentation) D. Rampulla, National Institute for Biomedical Imaging and Bioengineering (NIBIB), US
1:55	Gold Nanorods Induce Innate Immune Response and Reduce Respiratory Syncytial Virus Replication S. Bawage, P. Tiwari, A. Singh, S. Dixit, S. Pillai, V. Dennis, S. Singh, Alabama State University, US
2:15	Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer's Disease pathology following brain injury H.S. Sharma, D.F. Muresanu, J.V. Lafuente, R. Patnaik, Z.R. Tian, A. Ozikzilcik, H. Mössler, A. Sharma, Uppsala University, SE
2:35	Production of NSAID pharmaceutical molecular liquids via RESS processing S. Kumar Sharma, A.D. Woldetsadik, M. Magzouband, R. Jagannathan, New York University Abu Dhabi, AE
2:55	Novel method for topical and transdermal delivery of Nanomaterials S. Kalghatgi, A. Juluri, S. Stone, R. Gray, EP Technologies LLC, US
3:15	Using Cholesterol-based Nanoparticles to Achieve Unprecedented Silencing of Endogenous Genes (invited presentation) T. Anchordoquy, University of Colorado, School of Pharmacy, US

	Materials for Drug & Gene Delivery: Posters 3:30	Potomac Registration Hall
	Technological Challenges and Potential Advantages of Lipobeads as Drug Delivery Systems S. Kazakov, Pace University, US
	Self-assembling peptide dimers with multifunctionalities for gene delivery systems K. Ryu, G.J. Lee, T.-I. Kim, Seoul National University, KR
	The characterization and reductive degradation behavior study of bioreducible crosslinked polypropylenimine dendrimers for gene delivery systems G.J. Lee, K. Ryu, T.I. Kim, Seoul National University, KR
	TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer's Disease and brain pathology D.F. Muresanu, A. Sharma, J.V. Lafuente, R. Patnaik, Z.R. Tian, A. Ozikzilcik, H. Mössler, H.S. Sharma, University of Medicine & Pharmacy, RO
	Nanodelivery of drugs for therapeutic strategies in CNS disorders. Current and Future perspectives A. Sharma, D.F. Muresanu, J.V. Lafuente, R. Patnaik, Z.R. Tian, A. Ozikzilcik, H. Mössler, H.S. Sharma, Uppsala University, SE
	Folic Acid Conjugated Polymer as a New Active Tumor Targeting Drug Delivery Platform X. Li, M.R. Szewczuk, C. Malardier-Jugroot, Royal Military College of Canada, CA
	Timed release of cerebrolysin using titanate nanospheres induces neuroprotection in Parkinson’s Disease H.S. Sharma, D.F. Muresanu, J.V. Lafuente, A. Ozkizilcik, Z.R. Tian, R. Patnaik, H. Mössler, A. Sharma, Uppsala University, SE
	Microhydrogel Depot for Sustained Delivery of Protein Drug Y. Xu, Z. Zhou, B. Brooks, J. Miller, Luna Innovations Inc., US
	Skin permeation of hydrophobic drugs loaded into polymeric nanoparticles V.A. Feitosa, T.S. Balogh, K.L. Guimarães, M.H.A. Zanin, A.M. Oliveira, N.N.P. Cerize, Institute for Technological Research – IPT, BR
	Ferromagnetic Gd5Si4 Nanoparticles for Medical Applications C. Forney, Iowa State University, US
	Fabrication and Properties of Chitosan-Hydrocortisone-Silver Nanoshells S-Y Kwon, I-J Kang, Gachon University, KR
	Telomerase-specific Doxorubicin-releasing Molecular Beacon for Cancer Theranostics Y. Ma, Z. Wang, Y. Gu, China pharmaceutical university, CN
	An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA X. Zhang, Z. Wu, Hefei Institutes of Physical Science, Chinese Academy of Sciences, CN
	Preparation of isoniazid-coupled gold and silver nano-systems: Investigation on antibiotic corona and metal core reliant biological events P.N. Navya, H.K. Daima, siddaganga institute of technology, IN
	Nanofountain Probe Technology for In Vitro Single Cell Studies W. Kang, Naval Research Lab, US

Biocompatible materials with nano-scale structure hold great promise for controlled and targeted delivery and half-life extension of both small-molecule drugs and various classes of biologics, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Promising delivery systems include microcapsules, liposomes, macromolecular conjugates, nanoparticles, dendrimers, and biological stuctures such polypeptides, benign viruses and bacteriophages. This symposium will focus on commercially promising new materials and approaches.