An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA

X. Zhang, Z. Wu
Hefei Institutes of Physical Science, Chinese Academy of Sciences,

Keywords: mesoporous silica, DNA, enzyme-responsive, controlled release


An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could act as gates for storage of drugs. When DNase I enzyme was added, the DNA could be hydrolyzed to plenty of tiny fragments through the hydrolysis effect of DNase I, and obviously, the gates started to open and drugs loaded in the mesopores of MSN could be released. The system showed an excellent drug release performance, and was expected to be helpful to increase the treatment efficiency of drugs.