A Novel Device for In-Vitro Electromagnetic Modulation

B. Eckert, H. Truong, H. Kim, M. Izadjoo
Trideum Biosciences and ChiScan,
United States

Keywords: device, electromagnetic, modultation, cold plasma


Our in-vitro experiments with cold plasma discharge have demonstrated frequency dependent modulation effects. If a large number of cold plasma discharges with different modulation frequencies can be generated at the same time, the time required to search for an optimal frequency for a given biological effect is correspondingly reduced. Our technology is designed to use a standard 96 well polystyrene micro-plate as a basis for studying modulation frequency dependent electromagnetic effects on bacterial, fungal or viral cultures. A set of up to 96 square wave frequency generators is implemented with a Xilinx Artix-7 FPGA. These signals modulate electrical array elements which sit below each well in the micro-plate. Temperature control of the electrical array also allows culture incubation. The array modules are designed as different options, sharing a common digital controller and power supply design. The controller provides thermoelectric temperature control (heating and cooling), modulation generation and user interface. The user interface is a 2x20 OLED character display with push-button menu options, a memory card for experiment setup, and optional RS-485 MODBUS protocol. A typical experiment may use a large number of modulation array units. There are five different array options: 24 channel cold plasma, 96 channel RF near-field (2.4 GHz), 96 channel electric field (200Vp-p), 96 channel LED (IR, red, blue, UV etc.), and 96 channel magnetic field (vertical ferrite bars with solenoid coils).