S. Matiz Cely, L.A. Castillo, J.C. Cardenas, A. Reiber
Universidad de los Andes,
Keywords: nanoparticle, cancer treatment, lanthanides
Summary:Magnetic nanoparticles are studied mainly due to their super-paramagnetic properties and biomedical applications. The former is attained when a magnetic alloy has a single magnetic domain which is obtained when the critical size of a particle is small enough; the latter are drug delivery, contrast agents in magnetic resonance imaging (MRI) and magnetic hyperthermia. These particles are composed of an inorganic magnetic nucleus and an organic coating. Normally, the nucleus is made of magnetite and the coating varies according to the desired effect of the nanoparticle. The magnetic nucleus is our main interest because it could be enhanced by adding more magnetic elements for example lanthanides, like Europium, Gadolinium or Holmium. The organic coating would be 3-aminopropil-trimetoxysilane which can be bounded to proteins for further studies. In this study, we want to make metallic nuclei combining the following ferrites Fe3O4 or MnFe2O4 with lanthanide metals and identify changes in magnetism that could be produced. Furthermore, we want to obtain these metallic alloys in dispersed state to generate nanoparticles of those mixes.