Keywords: optical coherence tomography, space-division multiplexing, high speed, biomedical imaging
Summary:Label-free and non-destructive imaging technologies with micron-scale resolutions are greatly desirable for biomedical applications. Optical coherence tomography (OCT) is an emerging biomedical imaging technology that enables micron scale, cross sectional, and three-dimensional (3D) imaging of biological tissues noninvasively. OCT functions as a type of “optical biopsy,” imaging tissue microstructure with resolutions approaching that of standard histopathology, but without the need to remove and process tissue specimens.To date, OCT has been used in a wide range of clinical applications in humans, including ophthalmology, cardiology, endoscopy, urology, dermatology, and dentistry. Recently, we developed a space-division multiplexing OCT (SDM-OCT) technology that achieved over 20 times speed improvement compared to current state-of-the-art commercial OCT systems. With the SDM-OCT technology, high definition 3D scans of the eye can be acquired within a fraction of a second, instead of 3-10 seconds. This will significantly reduce motion artifacts, minimize procedure time, and improve procedure yields, diagnosis accuracy, and patient comfort. Furthermore, this technology can be inexpensively implemented in the next generation OCT devices, as well as retrofit into existing OCT devices. This technology will represent a significant competitive advantage for the OCT device company in the highly competitive, nearly $1B OCT device market.