Hyaluronan-modified Magnetic Hydroxyapatite Nanoparticles for Hyperthermia

H.-C. Wu, S.-Y. Hsieh, T.-W. Wang
Tatung University, TW

Keywords: bioceramic, magnetic nanoparticles, hyperthermia cancer therapy


The success of tumor therapy is determined by the efficiency with which the killing of tumor cells is achieved under conditions of no or only slight damage to the normal tissues. Because of its high tumor specificity and biocompatibility, hyaluronic acid (HA) could be potentially used for the design of tumor-targeting marker. HA, one of the major components of vertebrate tissue and body fluid, has been known to interact with the hyaluronan receptor, CD44. HA-CD44 binding triggers intracellular signals that influence cellular proliferation, differentiation, and migration. In this study, HA modified magnetic hydroxyapatite ( HA-modified mHAP) nanoparticles were newly developed and synthesized by wet chemical precipitation process. The result demonstrated that PEG spacer arm and HA targeting moiety were successfully immobilization on the surface of mHAP. Moreover, it possessed relatively good biocompatibility, adequate biodegradation rate and superparamagnetic property. In summary, HA-modified mHAP could not only be localized in site, generating heat within applied external magnetic field, but also be detected and observed by MRI in medical applications.