Stability of Functionalized Magnetic Particles in a Physiologic Fluid

K. Baca Ramos, C.A. Martínez Pérez, C.A. Rodríguez-González, H. Camacho-Montes, I. Olivas Armendáriz, A. Martel, P.E. García-Casillas
Universidad Autonoma de Ciudad Juarez, MX

Keywords: magnetite, chitosan, silica, adipic acid


Magnetic materials are widely used in biomedical applications such as magnetic separation, magnetic resonance imaging, drug delivery and hyperthermia. In these applications the nanoparticles are functionalized in a core/shell type with polymeric materials which contains active functional groups that are conjugated with biomolecules such as proteins, drugs, antibodies and they are isolated by applying an external magnetic field. The stability of the shell in biomedical applications is very important in order to protect the magnetic core, as well as to protect the human body in the case of “in vivo applications”. For this reason this paper describes the evaluation of magnetite nanoparticles with an average size of 13 nm covered in a core/shell type; magnetite/silica, magnetite/adipic acid, magnetite/chitosan, magnetite/silica/adipic acid and magnetite/silica/chitosan in a physiologic fluid. The double shell effect on the stability and the mechanism for the functionalization of the nanoparticles with a single and double shell were studied by Infrared spectroscopy (FTIR), Scanning electron microscopy was used to determine the particle size of the core and the physiologic fluid stability study was performed in an incubator chamber.