Assessing the Antimicrobial Activity of Silver Nanoparticles Leached from Medical Devices

B.J. Casey, B.J. Dair
U.S. Food and Drug Administration, US

Keywords: silver nanoparticle, characterization, antimicrobial, medical device


This work focuses on characterization the leachables released from substrates, e.g. medical devices, containing silver nanoparticles. Furthermore, antimicrobial experiments were conducted to determine how the structure of a silver nanoparticle impact antimicrobial activity. Proper characterization of nanoparticulate leachables is vital since size, structure, and chemistry all have a large impact on safety and antimicrobial efficacy.