Novel Catalysis of Dendrimer: Efficient Nanocavity of Polyamine Dendrimer for Intramolecular Michael Reaction

Z. Maeno, T. Mitsudome, T. Mizugaki, K. Jitsukawa, K. Kaneda
Osaka University, JP

Keywords: dendrimer, organocatalyst, Michael reaction


The intramolecular Michael reaction of (E)-9-nitro-3-nonen-2-one was investigated using poly(propylene imine) dendrimers with alkyl chain on the periphery (Gx-C16, x = 3-5, x denotes the number of the generation). Gx-C16 showed higher catalytic activity than low-molecular-weight tertiary amines. The catalytic activity of Gx-C16 increased with increasing the generation of the dendrimer. The sterically confined nanocavity of G5-C16 played a key role to achieve high catalytic efficiency.