Controlled- Release Antibiotic Nanoparticles for Cranial Transplantation and Bone Grafting

A.N. Adusumilli, S. Dammalapati, P.K.-L. Fu
Governors State University, US

Keywords: controlled- release, cranial transplantation, bone grafting


The objective of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This study involves three major components: first, encapsulate both hydrophobic antibiotics and hydrophilic antibiotics into nanoparticles. Second, incorporate antibiotic nanoparticles in a polymeric coating material (nitrocellulose plus 7.0% (w/v) polyvinylpyrrolidone) with a volatile carrier solvent such as ethyl acetate. Third, directly apply the resulting product from component 1 and 2 to polymethyl methacrylate (PMMA) cranial implants and hydroxylapatite (HA) bone grafting materials directly before surgery. When the volatile carrier solvent evaporates, the coating polymer with embedded antibiotic nanoparticles will form a thin film that is capably attached to the surface of the implant material. Local application of encapsulated antibiotics directly to the surgical sites can provide a non-oral, non-intravenous, controlled time-release treatment, which would allow continuous administration of antibiotic therapy over the prescribed time span of the individual antibiotics used. Our study provides a novel chemotherapeutic regime for the prevention and treatment of bacterial, fungal, and viral infections often occurred in cranial/bone transplant patients with a more efficient effective dose.