Understanding How Nanopatterning Affects Protein Deposition

B.J. Casey, J.S. Silverstein, P. Kofinas, B.J. Dair
U.S. Food and Drug Administration, US

Keywords: nanotopology, protein adsorption, block copolymer, thiol-ene


This work focuses on understanding the effects that nanotopology has on protein adsorption. Functionalized block copolymers were synthesized and processed to produced highly ordered, nanopattered films. Experiments utilizing a quart crystal microbalance were completed to investigate the impact that nanopatterning has on protein deposition/adsorption under static and dynamic conditions.