Nanostructured cellulose materials: adsorption of antibiotics onto cellulose fibers functionalized with glycidylmethacrylate for the manufacturing of antibacterial fabrics

E. Vismara, G. Torri, A. Valerio, G. Graziani, A. Montanelli, L. Melone
Politecnico di Milano, IT

Keywords: cellulose glycidylmethacrylate infections antibiotics


Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb amoxicillin and vancomycin, two different antibiotics largely used in the clinical activity. The reversible adsorption capacity can be modulated by simple chemical treatments after the grafting of GMA on the cellulose backbone, through the epoxy ring opening by addition of water molecules or primary diamines having different aliphatic chain length (2 to 6 C atoms). The pristine cellulose fibers have no any adsorption capability. Such materials can find suitable application as wounds dressing or more in general for the topical administration of drugs.