Lipid Nanoparticles as Novel Carrier for Broad-spectrum Sunscreen Formulations

X.Y. Deng, H.J. Zhou, Y.L. Chen, J.M. Wang, Q. Xia
Southeast University, CN

Keywords: avobenzone, NLC, sunscreens, HPLC


The most widely used UVA absorber in broad-spectrum sunscreens is 4-tert-butyl-4’-methoxydibenzoylmethane (avobenzone). In the sunlight, however, it will be photolysised rapidly and its photoprotection against UVA will greatly decrease. A photoprotective formulationwas developed with an increased sun protection factor(SPF), compared to a conventional formulations, but having the same concentration. In the present paper, the effectiveness of a sunscreen mixture, incorporated into the novel topical delivery systems, i.e. solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), used as ultraviolet (UV) protector enhancers with a distinctly higher loading capacity has been developed and evaluated. After the production by hot high pressure homogenization, the NLC were analyzed in terms of particle size, physical state, particle shape, ultraviolet absorbance and stability. The determination of 3 organic UV filters was performed by HPLC with UV spectrophotometric detection. The loading capacities for molecular sunscreens reported before now are in the range of 10–15%. It was possible to load NLC with up to 40% with molecular sunscreen.