A thin polymer coating protects individual drug crystals from adverse environments and allows for controlled drug release. Current methods of producing such coatings are very demanding batch processes. Employing hollow-fiber membranes NJIT developed two easily-scalable techniques for continuous polymer coating of drug crystals/nanoparticles using cooling crystallization or anti-solvent crystallization.
Primary Application Area: Biotech, Pharma
Technology Development Status: Proven Manufacturability
FIGURES OF MERIT
Value Proposition: Both techniques, SHFCC and PHFAC, are simple and straightforward, and easily scaled up. Just vary the number of polymeric hollow fibers in the device: make the shell of the device larger or smaller for higher or lower production rates. Maintain the same residence time and/or the flow rate ratios as the case may be. Such types of devices are being used in very large scale in industries employed in separation, purification and water treatment and could be easily adopted for continuous production of polymer-coated crystals, submicron particles and nanoparticles.
These devices are cheap, easily reused and employed for different systems.
High production rate for polymer-coated drug or particle/nanoparticle is easily achieved.
The results are highly reproducible
Organization Type: Academic/Gov Lab
GOVT/EXTERNAL FUNDING SOURCES