A novel chimeric drug candidate for treatment of human metastatic melanoma
A novel molecular chimera, CM358, for the treatment of a variety of cancers and specifically in treating human metastatic melanoma. The drug effectively inhibits human metastatic melanoma growth of tumor in xenograft model while exhibiting high survival rate without reduction of weight. This technology addresses a $1B drug market.
Novel Drugs Targeting Inflammatory Pathologies Based on a Core-Technology-Platform
Members of the Platform constitute families of complexes, each synthesized from 2 components. Each Member of the Platform is a potent anti-inflammatory agent, strong iron chelator, and antibiotic agent. Jointly, these 3 synergistic-parallel Mechanisms Of Action ensure therapeutic effectiveness in treating symptoms and causes of multiple indications.
Inventors at Georgia Tech and the University of Colorado have developed a method to capture sites of rNMP incorporation in genomic DNA. The method allows the analysis of the sites of rNMP incorporation with high-throughput sequencing and identification of the profile of rNMP incorporation in genomic DNA.
Screening Method for the Anti-Cancer Substance Hindering the Functions of TMF4SF5 and the Anti-Cancer Composite Containing Chalcone Compound
Screening method for TMF4SF5 anti-cancer substance and the anti-cancer composite using this. This compound improves functions of the anti-cancer compound and reduces external damage and toxic reaction to maximize the anti-cancer effect by screening the substances that hinder production and transition of several cancer cells.
Novel neuroprotective strategies using TiO2 nanodelivery of cerebrolysin and mesenchymal stem cells for the treatment of blast head injury
Blast head injury (BHI) is complex comprising multifactorial forces like, concussive, piercing, explosive and lacerative tissue injuries in soldiers at the battle field. BHI is difficult to treat using available therapies. We found that TiO2 nanodelivery of cerebrolysin with mesenchymal stem cells has superior effects on neuroprotection in BHI.
Development of a Novel in-situ Gel Povidone Iodine Ophthalmic Drop for the Treatment of Viral Conjunctivitis
IVIEW develops an ion-sensitive in-situ gel-forming drug delivery system exhibits sol-to-gel phase transitions when instilling into the eye. The effective concentration of povidone iodine is maintained by the equilibrium between solution and the gel bound components resulting in a long lasting anti-viral, antimicrobial, and less irritation effect.
Molecular Diagnostics for Precision Medicine
Researchers and physicians have long believed that patient genetic information, properly defined and analyzed, could help them to predict which patients are more likely to survive or do better on specific therapeutic regimens instead of throwing everything at them. This is one approach to precision medicine.
Selenbact is range of veterinary products containing selenium nanoparticles with antibacterial properties, in special nanocomposite with polymeric substance creating gel-like film preventing attachment and the growth of microorganisms responsible for infections. Nanocomposite was developed and tested with emphasis on maximum efficiency and for easier and effective application in veterinary field.
Continuous Polymer Coating of Drug Crystals, Particles and Nanoparticles
A thin polymer coating protects individual drug crystals from adverse environments and allows for controlled drug release. Current methods of producing such coatings are very demanding batch processes. Employing hollow-fiber membranes NJIT developed two easily-scalable techniques for continuous polymer coating of drug crystals/nanoparticles using cooling crystallization or anti-solvent crystallization.
New York, NY
A platform technology to activate a targeted immune response to selected tumor types
Our technology activates and targets two immune responses to attack, infiltrate and destroy tumors. It works by selectively activating dendritic cells (which control the immune sytem) and targeting their response to cells that present a cancer specific protein. We can engineer this response to any protein, therefore many different tumors.
Rapid and Sensitive Pathogen Detection System
The foodborne pathogen detection device will sense for the presence of harmful bacteria in the food that we consume. Companies in the food industry will protect themselves from liability and also protect their customer from food borne illness (food poisoning), which can lead to death depending on pathogen.
Novel HIV vaccine
This recombinant vaccine optimises anti-viral host responses, both in mucosal tissue and systemically, using a new adjuvant strategy and delivery regimen. Currently in late preclinical trials, the vaccine shows strong potential for treatment and immunization against HIV. The strategy is a platform technology with applications against other intracellular pathogens.
Traumatic brain injury induced AlzheimerÃ¢â‚¬â„¢s disease is thwarted by co-administration of nanowired neprilysin and cerebrolysin
Military personnel are vulnerable to traumatic brain injuries (TBI) and AlzheimerÃ¢â‚¬â„¢s disease (AD) as evidences with increased levels amyloid beta peptide in the cerebrospinal fluid and brain parenchyma. We found that co-administration of nanowired neprilysin and cerebrolysin prevented increased AÃŽÂ²P levels in brain thus mitigating AD pathology.
Preventing brain damage by co-administration of nanowired cerebrolysin with TNF-alpha antibodies in concussive head injury following sleep deprivation
Sleep deprivation in military is very common. When concussive head injury occurs in sleep deprived soldiers, the magnitude and intensity of brain damage is enhanced. We found that co-administration of nanowired cerebrolysin with tumor necrosis factor alpha antibodies remarkably reduce brain damage and improve functional recovery.