Antiadhesive Antithrombotic and Antimicrobial Coatings for Implants and Devices

J.N. Kizhakkedathu
University of British Columbia,
Canada

Keywords: antimicrobial coatings, antithrombotic surfaces, antimicrobial peptides, polymer brushes, polymer coatings, animal models

Summary:

Synthetic polymers have played critical roles in the success of many clinical applications and are widely used for drug delivery, drug conjugation and as implants. Focus of our laboratory at the Centre for Blood Research, University of British Columbia (www.cbr.ubc.ca) is tailoring the molecular level interactions of synthetic polymers with biological systems to design novel biomaterials in a translational setting to address unmet clinical needs. Thrombus formation and bacterial attachment pose major challenges to the optimal performance of indwelling catheters and devices. For example, catheter-associated urinary tract infections (CAUTIs) represent one of the most common hospital acquired infections with significant economic consequences and increased patient morbidity. Antimicrobial and antithrombotic coatings offer a significant step to address this important clinical problem. In the first part, I will discuss various strategies we developed based on anti-adhesive polymer brush coating towards antithrombotic coating. The influence of polymer structure and architecture on the surface influencing blood coagulation, platelet binding and innate immune response on polymer brush coated surfaces. In the second part, antimicrobial coatings based on tethered antimicrobial peptides (AMPs) on hydrophilic polymer brushes that shown resistance to biofilm formation and broad spectrum activity will be discussed. Finally, translation of the developed technology onto a clinically relevant biomedical plastic, polyureathane (PU) catheters, and the demonstration of the anti-adhesive coating to prevent catheter-associated urinary tract infections in a mouse model will be presented. References: Yu K et al Colloids and Surfaces B: Biointerfaces 2014, 124, 69-79; Yu K et al ACS Nano 2014, 8 (8), 7687-7703; Yu K et al Advanced Healthcare Materials 2012, 1 (2), 199-213; Hadjesfandiari, N et al Journal of Materials Chemistry B. 2014, 2 (31), 4968-4978; Gao et al Biomaterials 2011, 32 (16), 3899-3909; Yu K et al ACS Applied Materials and Interfaces 2015;7(51):28591-605; Yu K et al Biomaterials 2015, 69:201-11; Yu K et al Biomaterials 2017;116:69-81.