Keywords: biosensors, design
Summary:Living cells have an inherent need to monitor and respond to their biochemical milieu with consequences that result in life or death. Evolution therefore has arrived at high performing and robust solutions for cellular sensing. Cells exhibit many advanced performance features that have yet to be replicated in human-designed nano/microsensors. We therefore can build next generation biosensors by elucidating and abstracting the design principles underlying natural cellular sensing and reapplying them to human applications. In this talk I will examine some of these cellular design principles using examples, such as the vertebrate photoreceptor as case studies; and propose how these principles can be applied to engineered nano and microsensors.