Stimuli-sensitive Theranostic for Targeted Imaging-Guided Drug Delivery

Y. Haik
Hamad bin Khalifa University,
Qatar

Keywords: MRI contrast, MnZnGdFeO nanoparticles, thermosensitive

Summary:

Cancer is a major cause of death worldwide. Conventional delivery methods of chemotherapeutics cause serious, sometimes lethal toxicity due to their off-target effects. Hence, targeted, stimuli-responsive, drug bearing shells coupled with non-invasive monitoring holds the potential to provide site-specific therapy, trigger drug release and remote monitoring; thus providing better spatial and temporal control of therapy. This strategy minimizes the side effects associated with cancer drugs by directly carrying the payload to the cancer tissue and releasing it in controlled and sustained manner. We have synthesized thermosensitive polymeric drug bearing shells containing MnZnGdFeO4 magnetic nanoparticles (MNPs) as drug release, MRI imaging and thermometry agent. These MNPs demonstrated self-controlled temperature rise ability when subjected to alternating magnetic fields. The MNPs showed higher relaxivity than Gd making it superior for noninvasive monitoring of drug delivery to targets and has been demonstrated for its ability to monitor thermal elevation at treatment sites. Noninvasive thermometry monitoring system may be used to control the release of the drug load at the targeted tissue as well monitoring of drug delivery on site. This controlled release can be achieved by matching the temperature at the targeted tissue to the desired temperature that allows the thermosensitive nanoshell to release the drug load. In this presentation we will demonstrate the integration of our MNP with existing complementary modalities of diagnosis and therapy that enables non-invasive monitoring and guiding of interventions without having to change the environment.