TechConnect World 2016
National SBIR/STTR Conference National Innovation Summit & Showcase Nanotech 2016

Nanotechnology for Medical Diagnostics and Treatment

Nanotechnology for Medical Pictures

Sunday, May 22, 2016, 9:00 am - 5:00 pm, Gaylord National Convention Center, Washington, DC

Technology Focus

Nanotechnology has the potential to have a revolutionary impact on medical diagnosis and therapy. It is universally accepted that early detection of cancer is essential even before anatomic anomalies are visible. A major challenge in cancer diagnosis in the 21st century is to be able to determine the exact relationship between cancer biomarkers and the clinical pathology, as well as, to be able to non-invasively detect tumors at an early stage for maximum therapeutic benefit. For breast cancer, for instance, the goal of molecular imaging is to be able to accurately diagnose when the tumor mass has approximately 100-1000 cells, as opposed to the current techniques like mammography, which require more than a million cells for accurate clinical diagnosis.

In cancer therapy, targeting and localized delivery are the key challenges. To wage an effective war against cancer, we have to have the ability to selectively attack the cancer cells, while saving the normal tissue from excessive burdens of drug toxicity. However, because many anticancer drugs are designed to simply kill cancer cells, often in a semi-specific fashion, the distribution of anticancer drugs in healthy organs or tissues is especially undesirable due to the potential for severe side effects. Consequently, systemic application of these drugs often causes severe side effects in other tissues (e.g. bone marrow suppression, cardiomyopathy, neurotoxicity), which greatly limits the maximal allowable dose of the drug. In addition, rapid elimination and widespread distribution into non-targeted organs and tissues requires the administration of a drug in large quantities, which is often not economical and sometimes complicated due to non-specific toxicity. This vicious cycle of large doses and the concurrent toxicity is a major limitation of current cancer therapy. In many instances, it has been observed that the patient succumbs to the ill effects of the drug toxicity far earlier than the tumor burden.

Workshop Objectives

This workshop will address the state of the art in nanotechnologies and nano-medicine, and their ongoing applications focused on addressing the challenges posed by cancer prevention, diagnosis and treatment. Distinguished instructors will summarize the basics of nanotechnology and cancer biology, along with the current technologies, trials and future barriers. This program is designed to inform cancer researchers, clinicians, bio-nano technologists, technology managers, and business developers of the state of the art in bio nano technologies, focusing on applications of these technologies for cancer prevention, diagnosis and treatment.

Workshop Outline

Introduction

Nanotechnology for Cancer – Overview

  • Cancer biology fundamentals
  • Physiology of tumorigenesis, vasculature, etc.
  • Clinical aspects and current approaches
  • Unmet needs in clinical setting

Nanotechnology for Imaging - detection and therapy

  • Fluorophores and Quantum dots
  • Labeling and functionalization
  • Image analysis
  • Imaging facilitating surgical approaches

Nanotechnology for Cancer Therapy

  • Challenges in cancer therapy
  • Role of nanotechnology in cancer therapy
  • Nanotechnology platforms
  • Properties of nanoplatforms

Nanotechnology for Cancer Therapy

  • Passive versus active targeting
  • Tumor-targeted drug delivery systems (DNA, siRNA, etc)
  • Nanoparticles: silica, vesicles, dendrimers, etc.
  • Drug encapsulation strategies
  • Multifunctional nanotherapeutics
  • Radio-sensitization and tumor ablation with nanoparticles
  • Discussion

Nanotechnology in Cancer Research 1

  • Genome and proteome perturbations: overview
  • Protein and nucleic acid markers: handle for early detection
  • Current methodology and instrumentation
  • Limitations

Nanotechnology in Cancer Research 2

  • Why miniaturize?
  • Advanced separations: fluidics
  • Interfaces to measurement techniques
  • Cantilevers

Nanotechnology for Cancer Diagnosis and Treatment

  • Wrap-up discussion

Workshop Instructors

Mansoor M. AmijiMansoor M. Amiji
Distinguished Professor & Chair, Dept. of Pharmaceutical Sciences, Co-Director, Nanomedicine Education & Research Consortium
Northeastern University

Srinivas IyerSrinivas Iyer
Group Leader, Bioscience Division
Los Alamos National Laboratory


 

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