Anchored Immersion Microplate (AIM) Lids enable the use of standard microplates for 3D cell culture while remaining fully compatible with all aspects of high-throughput screening infrastructure. These functional lids securely anchor precise microliter hydrogel or core-shell droplets containing cells that can be repeatedly immersed into media in standard microplates.
Primary Application Area: Biotech, Pharma
Technology Development Status: Proven Manufacturability
FIGURES OF MERIT
Value Proposition: To improve the predictive outcomes of cell assays, researchers are moving to 3D cell culture wherein cell aggregates/spheroids or individual cells are suspended and cultured in hydrogel. Other changes to lower costs and improve outcomes include: reducing quantities of primary cells and expensive reagents; simplifying medium exchange; recovering cells for further culturing; and tracking the response of the same cells over many days/weeks. AIM Lids by ARLD provide a unique solution that meets these needs for predictive, low-cost 3D cell culture tools.
There are two large markets where ARLD’s improved 3D culture tools can have major impacts: pharmaceuticals and cosmetics. Recent studies have shown that < 10% of new drugs receive FDA approval, as a result, average R & D spending per drug is over $4B. The global cosmetics industry is under intense pressure to stop animal testing. In response, a ~$3B global market for in-vitro cosmetics testing has developed. The introduction of improved 3D cell testing methods is forecast to accelerate the adoption of cell-based in-vitro testing. The total market for 3D cell culture technologies was estimated to be $586M in 2014 and is projected to grow to $2.2B by 2019, a CAGR of 30%.
Organization Type: Early-stage Startup (Seed)
Showcase Booth #: 49T
GOVT/EXTERNAL FUNDING SOURCES
Vetted Programs/Awards: The importance of ARLD’s work has been recognized by the Society for Laboratory Automation and Screening (SLAS). Our paper was accepted for a 30 minute podium presentation at the SLAS conference in January 2016, and ARLD will be showcasing our technology at booth #550 at the concurrent exhibition.
SBIR/STTR Awards: ARLD has been awarded Phase I and Phase II SBIR grants from the National Science Foundation: Phase I (Award #:1215288, $150 K) was received July 1st, 2012 and Phase II (Award #: 1330949, $940 K) began 9/1/2013