Fabrication and Properties of Chitosan-Hydrocortisone-Silver Nanoshells

S-Y Kwon, I-J Kang
Gachon University,
Korea

Keywords: chitosan nanoparticles, silver nanoshell, drug carrier

Summary:

Drug delivery system(DDS) havs been widely examined by biomedical applications over the past several decades. Drugs could be processed into a dosage form suited to easy application and optimal treatment effects; these drugs can be administered in several methods. Drugs can show their effects when they reach the target zone in the living body; if the drugs do not arrive their destination, side effects are generaly observed. A drug delivery system is a systematic technology that efficiently delivers drugs to a target region for effective recovery and the decrease of side effects, but increasing our adaptation to them, resulting in obtaining the highest curing effect. If the drug exhibits pharmacodynamic properties such as high solubility, or insolubility, a modified delivery order is required. Former studies have focused on using large molecules as drug delivery carriers. To be adaptable as a drug delivery carrier, a drug carrier could resist changes in temperature, pH and other chemicals until it arrives its destination and emits the drug. Thus, the materials should be bio-applicable. The natural polymer produced by the deacetylation of chitin can be obtained from crustaceans. Chitosan exhibits a number of advantages because this polymer is nontoxic, biocompatible, biodegradable, and water-soluble. In addition, chitosan has a positive charge in slightly acidic solution, enabling it to form nanocomplexes through ionic interactions with negatively charged metallic nanoparticles. The nontoxicity of chitosan makes it particularly suitable for the delivery of anti-inflammatory drugs, antioxidants, antihypertensive drugs, anticancer drugs, and antidiabetic drugs. Chitosan is a biopolymer that is usually produced from N-deacetylation of chitin which is extracted from crustacean. It is emerging substance as the promising bio-adaptable material that is harmless to human body. Many researchers have been interested in the chitosan for drug delivery system because of merits such as good absorptivity, biodegradability, and biocompatibility. The drug used for the research was hydrocortisone, a steroid hormone. Hydrocortisone has been used to make allergic rhinitis medicine. This work was focused on the drug delivery through the nasal mucosa by using chitosan-hydrocortisone-silver nanoparticles. It was performed for an investigation in order to establish the optimal conditions, by changing concentration of hydrocortisone and reaction conditions. Silver nanoparticles have specific properties for the treatment of various diseases. Their extremely large surface area can collaborate with a vast number of ligands and prevent bacterial infections. The properties of silver nanoparticles applicable to patient treatments are under studying in many research groups and animal studies, assessing potential efficacy. In this reseach, the average size of chitosan-hydrocortisone-silver nanoshell was about 80 nm, was suitable as an drug carrier because maximum size of drug carrier in human body is 120 nm. UV-Vis spectra of chitosan-hydrocortisone-silver nanoshell show the characteristic peak of silver at 420 nm. Also, multi-layered silver nanoshell on the chitosan nanoparticles induced the red-shifted absorption peak and increased the intensity of absorption peak.