Neural Stem Cell Differentiation and Proliferation Promoted by Three-Dimensional Nano Matrixes

Z.F. Huang
Hong Kong Baptist University,
Hong Kong

Keywords: neural stem cell, differentiation, proliferation, 3D nano matrixes, glancing angle deposition

Summary:

Nowadays, neurodegenerative diseases, for example Alzheimer’s disease and Parkinson’s disease, are incurable. Stem cell replacement therapies have high potential to be a cure to neurodegenerative diseases, by means of restoring functions of a diseased brain via replacing damaged cells or cell loss with neural cells or healthy cells in-vitro developed from neural stem cells. Currently, embryonic stem cells and induced pluripotent stem cells are two commonly known stem cell sources; however, they are prone to have genetic instability, tumor formation, ethical issues and immune rejection due to the use of viral vectors for adult cell engineering and an excessive use of growth factors like VEGF, FGF and IFG. Concerning the practicalities of the prevalence of neurodegenerative diseases and the current stem cell therapies, academic researchers from Hong Kong Baptist University announced the successful development of ‘Autologous Stem Cell Harvest’ 2 years ago, which is not the end of the project but another starting point. This project is an extension of the previous project. It aims to investigate the relationship of nano matrixes, which have engineerable topographies and are composed of controllable materials, and the differentiation and proliferation of neural stem cells, in order to enhance the respected rate of differentiation and proliferation of neural stem cells by pure mechanical stimulation without using any growth factors.