Synthesis and Characterization of a Bioresorbable Poly(L-co-D,L lactide) Based Adhesion Barrier Film

M.B. Güner, A.B. Yoruç Hazar
Yıldız Technical University,
Turkey

Keywords: Poly(L-co-D, L lactide), adhesion prevention, adhesion barrier film

Summary:

Tissue adhesion is an uncomfortable situations for patients that could be usually seen and causes seriously pains, dysfunctions of organs or repeatative operations. While wound healing process, ECM deposits on the scar surface because of the covering of the inflammatory cells and fibroblasts more than mesothelial cells. ECM molecules, that is synthesized by fibroblasts and placed on the scared tissue surface, causes adherence to the neighbour tissues and organs with the weak fibrous linkages. On the other hand, with the gradual vascularization and deposition of collagen on the wound tissue, undesired tissue adhesion occurs. Tissue adhesion prevention barriers place between wounded tissues and neighbour tissues or organs for preventing the adhesion mechanism during wound healing process. Thanks to this prevention, contact of the wounded tissues and neighbour tissues or organs are cut and uncomfortable or economically issues are overcomed. Bioresorbable materials are eliminated from human body methabolismally with the in vivo size reduction and bioabsorbtion. Bioresorbing mechanism aims the elimination of the biomaterial totally without any side effects at the end of the usage life. Nowadays, researches, that are focused on the bioresorbable materials, gathered around the poly(lactic acid) types, that contains α-hydroxylic acid, such as poly(L-lactic acid), poly(D-lactic acid), poly(D, L-lactic acid) adn poly(glycolic acid), polycaprolactone, polyhydroxybutyrate and copolymers of these polymers. PLA is the most important polymer that replaces petroleum based products. PLA is produced from %100 renewable resources such as sugar, corn, potato, sugar beet and cane. The most prefered industrially method for producing PLA is the ring opening polymerization of lactide, that is depolymerization product of the lactic acid. Ring opening polymerization enables to produce polymers that has got 1.000.000 g/mol molecular weight with the production parameters between 100-1000 ppm catalyst concentration, 140-180°C and 2-5 hours. Solvent casting method is the most common method of PLA based film production. Solvent casting method provides uniform thickness, maximum optical transperancy and minimum brightness. These properties enhances the usage of solvent casting method for film production. In this study firstly, lactide isomers are polymerised with ring opening polymerization, than solvent casting is applied to synthesized polymers to produce films for tissue adhesion prevention with %100 biorenewable resources and finally characterization works is going to be done to asses quality of the produced films and effects of the precursors and parameters on the films.