Solving Drug Delivery Problems by Genetically Engineered Nanoparticles

A. Chilkoti
Duke University,
United States

Keywords: drug delivery, nanoparticles

Summary:

I will summarize a new drug delivery system that we have developed for small molecule cancer chemotherapeutics. This methodology —attachment-triggered self-assembly of recombinant peptide polymers— can package small molecule cancer drugs with a range of hydrophobicity into soluble nanoparticles of a recombinant peptide polymer. These nanoparticles increase the solubility, plasma half-life, and tumor accumulation of the drug, which translates to improved efficacy of the nanoparticle formulation as compared to free drug. Examples of encapsulating doxorubicin, paclitaxel, and gemcitabine —three drugs with vastly different structures and physico-chemical properties— will be presented to illustrate the versatility of this new technology for drug delivery.