Questions Surrounding the use of PEGylation for Intracellular Delivery

T. Anchordoquy
University of Colorado, School of Pharmacy,
United States

Keywords: cholesterol, nanoparticles

Summary:

The use of components conjugated to polyethylene glycol (PEG) have been used for decades to extend circulation lifetimes of nanoparticles, with the hope of enhancing accumulation in tumors via the Enhanced Permeation and Retention effect. Although many studies have reported extended circulation times by employing PEGylated nanoparticles, very few have observed enhanced accumulation and delivery to the tumor. This talk will review some of the early work with PEGylated liposomes and the conclusions drawn from clinical studies. In addition, we will discuss the potential mechanisms responsible for extending circulation times, as well as more recent results suggesting that PEGylated components might be immunogenic and elicit adverse effects on tumor growth.