Advanced Materials Characterization Techniques for Modern Pharmaceutical Development

M. Lamm
Merck,
United States

Keywords: drug formulation, advanced materials

Summary:

The development of effective medicines requires not only discovery of potent and selective compounds (active pharmaceutical ingredients) but also a formulation capable of achieving the desired pharmacokinetic profile. In addition, the formulation must be chemically and physically stable over the shelf life of the product throughout the varying climates of the world. The formulation process must be robust, scalable, and cost efficient. To meet these needs, modern pharmaceutical formulations employ complex compositional and processing strategies to overcome challenges such as low aqueous solubility or poor chemical stability. Effective design and understanding of formulation structure-property-performance relationships requires an increasingly sophisticated set of materials characterization tools. In this presentation, applications of some of these tools to pharmaceutical development will be highlighted with a particular emphasis on scanning probe techniques.