Traumatic brain injury repair with neurotropic factors and coral scaffold
A breakthrough method for nervous tissue repair using a graft system for regenerative medicine of injured brain and spinal cord, with implications for therapy of tissue loss following neurodegenerative diseases. It's based on synchronous usage of two components: a novel material mixture and a bioactive coral skelton scaffold
Nanowired delivery of mesenchymal stem cells (MSCs) attenuates pathophysiology of spinal cord injury and enhances brain derived neurotrophic factor and insulin like growth factor-1 concentrations in the plasma and the spinal cord
We found that mesenchymal stem cells (MSCs) given before spinal cord injury (SCI) attenuates functional recovery and cord pathology at 12 h however TiO2-nanodelivery thwarted cord pathology and improve functional recovery after 12 and 24 h SCI indicating that nanodrug delivery of MSCs has superior neuroprotective effects in SCI.
FLOWPAD is a generic microfluidics platform that responds to the need for miniaturization and integration of laboratory procedures into lab-on-chip devices. Depending of the design of the consumable microfluidic cartridge, FLOWPAD is able to address biology, healthcare, security or environmental applications
A portable, hand-held device that can detect and identify bacteria in fluids (water, blood, urine etc.) in under 30 minutes as opposed to the current standard of 24-48 hours. It uses a patent-pending silicon technology developed at Yale University to detect single bacteria directly, without any need for culture growth.
Diagnosis of Kidney diseases
Diagnosis of kidney diseases via urinary proteins This technology is designed to easily detect various kidney diseases including chronic renal failure, acute renal failure, IgA nephropathy, diabetic nephropathy, and so on. In addition, this technology evaluates prognosis of kidney diseases.
A Lab to the sample concept technology combining sensors and communication platforms to deliver real time in-situ data. By automating sampling and measurement, manual interventions are eliminated, providing accurate scientific data directly from the sample to mobile devices.
Solid-State Fermentation for Production of Succinic Acid from Renewable Biomass
This technology relates to the use of solid-state fermentation to produce succinic acid from sugarcane bagasse. Succinic acid produced via this method is highly concentrated (~80%) and incurs much lower purification costs compared to submerged ferementation where energy intensive purifications eg distillation is used for purification.
Nano-size carbon dots for neurotheranostics
Fluorescent nano-sized particles, Carbon dots, synthesized from definite carbohydrates for modulation of key processes in brain nerve terminals; for labelling and visualization of membrane compartments in the cells and usage in theranostics
High Throughput Quantitative Assessment of Complex Plant Traits and Physiological Responses
Innovative methods to better predict the field performance of novel plant genetics and/or new agricultural technologies that affect complex plant traits will be developed in a high-throughput greenhouse and field plant phenotyping (HTPPC) center, established to provide services to a broad spectrum of public and private plant research entities.
Chemotherapy wafer to treat oral cancer topically
Our ChemoThin Wafer (CTW) is a polymeric mesh that hold chemotherapy nano-particles. upon hydration, it releases the nano particles along with other excipients directly into the tumor. The CTW is unidirectional mucoadhesive wafer that remain in place and can be removed after one hour of appliction.
Miniature Acoustic Cellular Disruption and Biological Detection using Acoustic Wave Biosensor
The miniature acoustic cellular disruption technology releases viable DNA, RNA, and proteins from human or bacterial cells, without chemicals or additional processing, to enable high-speed sample preparation for clinical point-of-care (POC) medical diagnostics and use with nano/microfluidic devices.
Transdermal Microneedle Sensors
We are developing a wearable point of care diagnostic system capable of monitoring an individualâ€™s local and systemic physiological state based on transdermal microneedle sensors. Such a minimally invasive sensor has applications in home health care, sports medicine, and defense of the warfighter.
BaDx (Bacillus Anthracis Diagnostics)
BaDx is a stand-alone, diagnostics cartridge used in resource-limited and challenging environments to sense real-world concentrations (>100 spores) of virulent B. anthracis, the bacteria that causes anthrax infection.
Point of Care Biosensor for Rapid Differential Diagnosis of Sepsis
We have developed and protected a technology to accurately deliver and control liquids in microchannels using capillary (surface tension) forces only. Our highly flexible liquid handling platform miniaturizes and automates existing laboratory procedures. We implemented the technology for making one-step highly sensitive point of care assays.
High yield process for the production of probiotic lactic acid bacteria biomass from unsupplemented whey
This technology is a process subject to produce biomass as probiotic and further protein primary product, dairy fat and lactic acid from whey using lactic acid bacteria. The technology doesn't require cold chain and we reduce the environment impact the milk whey produces
High Performance Nanoparticle-Based MRI Contrast Agent
We have developed a novel nanoparticle-based MRI contrast agent that shows efficacy an order of magnitude higher than current clinical MRI contrast agents, and is safe for use in patients with kidney problems for whom current clinical MRI contrast agents are restricted for use.
Multiplexed genome editing by natural transformation for accelerated evolution of microbes (MuGENT)
Researchers from Tufts have developed a novel method for multiplex genome editing in naturally competent microbes. This method offers unprecedented speed of evolution of traits and phenotypes and can become the foundation for the rapid development of custom-designed microbes which can be used in the broad spectrum of applications.
Nanoscale Coordination Polymers (NCP) for Platinum â€“Resistant Ovarian Cancer
NCP drug delivery platforms have the potential to overcome many drawbacks of existing drug delivery systems such as low drug loading. The NCP offers controlled drug cargo release, modular surface structures contribute to NCP targeting, lower drug dosage, and siRNA for added gene therapy in one formulation.
MRSA Antibody Therapeutic Simultaneously Treats and Vaccinates Against Reinfection
A monoclonal antibody that demonstrates effectiveness as both a treatment and vaccine for Staphylococcus aureus infections. The therapeutic antibody vaccine is effective in treating methicillin-resistant S. aureus (MRSA) infection by enabling bacterial killing and generating a protective immune response that prevents recurrence.
LIGHT: Immunotherapy for treatment of primary tumors and metastatic disease
LIGHT is a multiâ€pronged immunotherapeutic approach for the treatment of cancer. LIGHT supercharges an antiâ€tumor immune response by recruiting immune cells to tumor sites and by stimulating T cell activation. LIGHT therapy destroys distant metastases and creates immune memory, blocking cancer recurrence.
TiO2 nanowired Cerebrolysin for neuroprotection in concussive head injury
Our innovation shows that intravenous administration of TiO2 nanowired-tagged Cerebrolysin (Ever NeuroPharma, Austria) that is a balanced composition of several neurotrophic factors and active peptide fragments enhanced neuroprotection after concussive head injury (CHI) in rat model (5 ml/kg 1 to 2 h after CHI) as compared to normal cerebrolysin.
Depression in Military is effectively prevented by PLGA-encapsulated Cerebrolysin therapy
Depression in military is a serious problem in young boys and girls affecting performances. Deficiency of neurotrophic factors in the brain could be the cause. Our innovation shows that exogenous supplement of Cerebrolysin, containing selected neurotrophic factors prevented depression in model experiment that was most marked with PLGA encapsulated cerebrolysin.
A new orally-administered, systemic aminothiol radioprotector, with no nausea/hypotension side effects, with issued and pending patents; itâ€™s administered minutes before a CT scan to prevent the 30,000 CT-associated cancers/year that are estimated by NCI to occur in the U.S. alone. We estimate a $2.9 Billion annual market in the U.S.
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