TechConnect Innovation Program

Artificial metalloenzyme catalysts through directed evolution

University of Chicago, IL, United States

TECHNOLOGY SUMMARY

University of Chicago professor Jared Lewis uses “directed evolution” to develop new classes of “green” catalysts and general methods for catalyst engineering. Time-consuming, expensive conventional reaction steps may be replaced with a single efficient reaction step performed at moderate temperatures in aqueous buffers using engineered catalysts with good selectivity.

Primary Application Area: Materials & Chemical

Technology Development Status: Prototype

Technology Readiness Level: TRL 4

FIGURES OF MERIT

Value Proposition: Dr. Lewis’ catalysts reduce synthetic costs and accelerate diversified library construction by replacing circuitous synthetic sequences, protection and deprotection steps, and intermediate isolation and purification steps with a single reaction step.

SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Showcase Booth #: 637

Website: www.uchicago.edu

GOVT/EXTERNAL FUNDING SOURCES

Government Funding/Support to Date:

Primary Sources of Funding: Federal Grant

Looking for: Both Funding and Development Partners