Design and Synthesis of Novel Inhibitors of Isoprenoid Biosysnthesis
Northern Illinois University, Illinois, United States
This invention is a series of synthetic compounds designed to inhibit the enzyme IspF present in the MEP pathway. Compounds from this series will lead to improved drugs and other treatments for infectious diseases such as malaria and a range of bacterial infections. These compounds also demonstrate herbicidal capabilities.
Primary Application Area: Pharmaceuticals & Personal Care
Technology Development Status: Prototype
Technology Readiness Level: TRL 4
FIGURES OF MERIT
Value Proposition: The compounds discovered have antimalarial activity, antibacterial and herbicidal activity. If successful, the impact could be very large. There is a growing demand for new antibacterial agents, antimalarial agents and new herbicides. The compounds discovered have the potential to target all of these needs and markets.
Organization Type: Academic/Gov Lab
Showcase Booth #: 707
GOVT/EXTERNAL FUNDING SOURCES
Government Funding/Support to Date: 2014-2017 NSF; 2014-2019 National Inst. of Allergy and Infectious Dieseases/NIH/DHHS
Primary Sources of Funding: Federal Grant, University, Other
Looking for: Both Funding and Development Partners