TechConnect Innovation Program

Design and Synthesis of Novel Inhibitors of Isoprenoid Biosysnthesis

Northern Illinois University, Illinois, United States

TECHNOLOGY SUMMARY

This invention is a series of synthetic compounds designed to inhibit the enzyme IspF present in the MEP pathway. Compounds from this series will lead to improved drugs and other treatments for infectious diseases such as malaria and a range of bacterial infections. These compounds also demonstrate herbicidal capabilities.

Primary Application Area: Pharmaceuticals & Personal Care

Technology Development Status: Prototype

Technology Readiness Level: TRL 4

FIGURES OF MERIT

Value Proposition: The compounds discovered have antimalarial activity, antibacterial and herbicidal activity. If successful, the impact could be very large. There is a growing demand for new antibacterial agents, antimalarial agents and new herbicides. The compounds discovered have the potential to target all of these needs and markets.

SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Showcase Booth #: 707

Website: www.niu.edu

GOVT/EXTERNAL FUNDING SOURCES

Government Funding/Support to Date: 2014-2017 NSF; 2014-2019 National Inst. of Allergy and Infectious Dieseases/NIH/DHHS

Primary Sources of Funding: Federal Grant, University, Other

Looking for: Both Funding and Development Partners