TechConnect Innovation Program

Enzymes with robust, pH-tunable degradation selectivity for a broad range of polysaccharides

Lehigh University, Pennsylvania, United States

TECHNOLOGY SUMMARY

We have engineered low-cost, scalable production of a series of enzymes which can degrade specific polysaccharides at a chosen pH, including hyaluronic, mannuronic and celluronic acids. Enzymes exhibit broad pH and thermal stability. Specific applications include bacterial biofilm removal, degradation of plant biomass and as adjuvants to increase tissue permeability.

Primary Application Area: Pharmaceuticals & Personal Care

Technology Development Status: Prototype

Technology Readiness Level: TRL 4

FIGURES OF MERIT

Value Proposition: We can produce the bacterial enzyme at orders of magnitude reduced cost compared to competitors mammalian enzymes with superior activity, stability and solubility. Also, ability to engineer variants that regulate activity using pH will reduce side effects and increase efficacy in therapeutic and commercial food/cosmetic applications.

SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Showcase Booth #: 816

Website: www.lehigh.edu

GOVT/EXTERNAL FUNDING SOURCES

Government Funding/Support to Date:

Primary Sources of Funding: University, Other

Looking for: Both Funding and Development Partners