Ondansetron, a 5-HT3 receptor antagonist reduces major depression episodes exacerbated by nanoparticles intoxication
Uppsala University, Uppland, Sweden
Major depression (MD) in our military deployment is more prevalent in young women (18-25 age group) that could be exacerbated by nanoparticles (NPs) SiO2 and carbon exposure. We found that TiO2 nanowired ondansetron markedly reduces MD episodes in model experiments in female rats in such situations for the 1st time.
Primary Application Area: Biotech & Biological Sciences
Technology Development Status: Concept
Technology Readiness Level: TRL 3
FIGURES OF MERIT
Value Proposition: We need to develop this research further and go for long term treatment and post-treatment strategies to prevent or treat Major Depressive illnesses in Military especially affecting young female soldiers.
Organization Type: Academic/Gov Lab
Showcase Booth #: 636
GOVT/EXTERNAL FUNDING SOURCES
Government Funding/Support to Date: This work was partially supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065 for studies on biological effects of nanoparticles in the central nervous system (CNS) & Uppsala University, Uppsala, Sweden
Primary Sources of Funding: University, Other
Looking for: Funding