TechConnect Innovation Program

Ondansetron, a 5-HT3 receptor antagonist reduces major depression episodes exacerbated by nanoparticles intoxication

Uppsala University, Uppland, Sweden

TECHNOLOGY SUMMARY

Major depression (MD) in our military deployment is more prevalent in young women (18-25 age group) that could be exacerbated by nanoparticles (NPs) SiO2 and carbon exposure. We found that TiO2 nanowired ondansetron markedly reduces MD episodes in model experiments in female rats in such situations for the 1st time.

Primary Application Area: Biotech & Biological Sciences

Technology Development Status: Concept

Technology Readiness Level: TRL 3

FIGURES OF MERIT

Value Proposition: We need to develop this research further and go for long term treatment and post-treatment strategies to prevent or treat Major Depressive illnesses in Military especially affecting young female soldiers.

SHOWCASE SUMMARY

Organization Type: Academic/Gov Lab

Showcase Booth #: 636

Website: www.uu.se

GOVT/EXTERNAL FUNDING SOURCES

Government Funding/Support to Date: This work was partially supported by grants from the Air Force Office of Scientific Research (EOARD, London, UK), and Air Force Material Command, USAF, under grant number FA8655-05-1-3065 for studies on biological effects of nanoparticles in the central nervous system (CNS) & Uppsala University, Uppsala, Sweden

Primary Sources of Funding: University, Other

Looking for: Funding