Gel Microparticle System for Targeted Lung Delivery for the Treatment of Non-Small Cell Lung Cancer

N.M. Pinkerton, L. Shi, J. Wan, Z. Szekely, X. Zhang, P. Sinko, H.A. Stone, R.K. Prud’homme
Princeton University, US

Keywords: non small cell lung cancer, gel, delivery, nanoparticle, targeting

Summary:

Non-small cell lung cancer (NSCLC), a subset of lung cancer, encompasses a set of diseases with similar prognosis and treatments. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. We describe an approach to selectively target the lung to deliver hydrophobic anti-cancer drugs with controlled drug release..Delivery is by passive targeting of the lung via the venous blood stream. Large particles in the venous blood are thus trapped in these capillary beds. This filtering phenomenon can be used to selectively deliver particles to the lung. Such delivery methods have been safely employed in pulmonary perfusion diagnostic agents; however the use of this novel delivery route for chemotherapeutic drugs has not been appreciated or utilized by the drug delivery community. The targeting to the lungs is effected by size and modulus of the GMPs. GMPs with carefully tailored sizes between 10 and 40 microns are formed using microfluidics. The hydrolysis of the network controls the release of the NPs from the network.