Counting and Sizing Nanoparticles using Single Particle ICP-MS

C. Stephan, A. Hineman
PerkinElmer Inc, CA

Keywords: nanoparticle, sizing, counting, fate, dissolution, agglomeration


This work describes the theory and application of Single Particle- ICP-MS in analyzing Metal Based Nanoparticles. Single Particle (SP-ICP-MS) allow the differentiation between ionic and particulate signals, quantitate both the ionic and particulate fraction, measures particle concentration (part/mL), particle sizes (if shape is known), and explores agglomeration and size distribution. SP-ICP-MS is a key analytical instrument in assessing the fate, behavior and distribution of (ENMs) in several types of matrices (environment, food, etc.), evaluating ENMs bioavailability and bioaccumulation in the biota, and improving bio-labeling capabilities and advancements in the medical field.