Biodegradable Polymer-Based Composite Particles for Targeted Drug Delivery Carriers with Magnetic Response

Y. Kitamoto, C. Oka, K. Ushimaru, T. Tsuge, N. Horiishi
Tokyo Institute of Technology, JP

Keywords: biodegradable polymer, magnetic nanoparticle, core-shell


Core–shell composite particles with biodegradability and magnetism were prepared for targeted drug delivery based on magnetic guidance. The composite particles were composed of a core of biodegradable polymer and a shell of assembled magnetic iron oxide nanoparticles. They were prepared using a modified emulsification solvent diffusion method that involved the formation of a Pickering emulsion. The preparation was conducted via the formation of oil-in-water emulsion stabilized by iron oxide nanoparticles followed by the evaporation of the solvent of the polymer in the oil phase. The composite particles were also fabricated with a model drug loaded into the core, which was released via hydrolysis of the core. Because the core can also be biodegraded by lipase, the slow release of the drug from the composite particles should occur inside the body. The magnetic nanoparticles not only realize magnetic guidance of drug but also facilitate a second drug release mechanism via the melting of the polymer particles using the heat generated when exposed to an applied high frequency magnetic field. Therefore, the composite structure should lead to a magnetic drug carrier possessing two types of drug release mechanism: sustained release by biodegradation and rapid release by melting of polymer particles.