Controlled Synthesis of Monodisperse Magnetic Porous/Hollow Nanostructures for Biomedical Applications

K-S Kim, D.T. Nguyen
Kangwon National University, KR

Keywords: magnetite nanoparticles, one-pot solvothermal process, biomedical applications


Recently, studies on therapeutic applications of the magnetic nanoparticles have gained more momentum. The use of magnetic nanoparticles for hyperthermia has shown great promise in the field of nanobiomedicine. The porous/hollow structure also exhibited a great potential to encapsulate small drug molecules. Once inside the porous structures, small drug molecules would be shielded by the shell from fast reaction/deterioration in biological solutions. In our research, monodisperse magnetite Fe3O4 porous/hollow nanoparticles were successfully synthesized through one-pot solvothermal process without any surfactant and template. The Fe3O4 porous/hollow nanoparticles consisted of numerous tiny grains. Those particles were ferromagnetic with a high saturation magnetization. The Fe3O4 porous/hollow nanoparticles were synthesized controllably with tunable particle size and porosity by adjusting the initial concentrations of Fe precursor and ammonium acetate. The formation mechanism of the magnetite hollow spheres comprised simultaneous chemical and physical processes including the formation of numerous tiny grains, the spherical assembly of those grains and the chemical conversion coupled with the relocation of the grains. The porous/hollow nanoparticles could be further coupled with a specific targeting agent and be concentrated around the area of interest, where drug molecules would be released either chemically or physically through a magnetic stimulation and activation.