Synthesis of of Biopolymeric Nanoparticles Using Supercritical Carbon Dioxide as a Dispersion Medium

Y. Bakhbakhi, M. Alhazzaa, M.D. Putra, M. Asif
King Saud University, SA

Keywords: nanopoarticles, supercritical fluids, SCF, biopolymeric


The utilization of supercritical fluids (SCFs) can lead to the development of materials with unique chemical or physical characteristics that make them suitable for specialized applications. One such technique is synthesizing with supercritical fluids, where the unique fluid characteristics and properties of supercritical fluids are utilized. In this work, The Solution Enhanced Dispersion by Supercritical fluids (SEDS) process precipitation process has been employed to produce fine biopolymeric particles of Poly (L-Lactide) Acid (L-PLA) from dichloromethane (DCM) solution using CO2 as antisolvent. Submicron particles of L-PLA with uniform morphology have been obtained at all successful SEDS conditions. The ongoing study highlights the potential of a gaseous antisolvent process as an attractive and scalable technology for the synthesis of ultrafine particles for specialty chemical applications. See PDF for full abstract.