An emerging high throughput screening platform for engineered nanoparticle mediated genotoxicity

C. Watson, J. Ge, J. Cohen, G. Pyrgiotakis, B. Engelward, P. Demokritou
Harvard School of Public Health, US

Keywords: genotoxicity, Comet, DNA damage, CometChip, engineered nanoparticles

Summary:

We have created a more effective and high throughput genotoxicity platform using a preexisting technology called the CometChip. This platform could help to overcome current limitations in our ability to assess the vast libraries of new and existing engineered nanoparticles (ENPs) and would thus reduce potentially serious public health issues associated with ENP induced genotoxicity. Such a rapid screening assay can also be pivotal in our quest for developing safer by design nanomaterials and help in understanding the link between ENP property and genotoxicity.